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EC number: 202-624-0 | CAS number: 97-97-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethane, 2-Chloro-1,1-Dimethoxy-
- IUPAC Name:
- Ethane, 2-Chloro-1,1-Dimethoxy-
- Reference substance name:
- 97-97-02
- IUPAC Name:
- 97-97-02
- Reference substance name:
- 2-chloro-1,1-dimethoxyethane
- EC Number:
- 202-624-0
- EC Name:
- 2-chloro-1,1-dimethoxyethane
- Cas Number:
- 97-97-2
- Molecular formula:
- C4H9ClO2
- IUPAC Name:
- 2-chloro-1,1-dimethoxyethane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Chloroacetaldehyde dimethylacetal
- Physical state: colourless liquid
- Solubility in water: 52 g/L at 20°C
- pH: 3.4 at 10g/L (20°C)
Constituent 1
Constituent 2
Constituent 3
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra danio
- Source: West Aquarium, D-Bad Lauterberg
- Length at study initiation: 2-3cm
- Weight at study initiation: 0.35g in average
- Feeding during test: no
ACCLIMATION
- Acclimation period: 7d in test water befor study initiation
- Acclimation conditions (same as test or not): yes
- Type and amount of food: flakes (Tetra Min Hauptfutter)
- Feeding frequency: 3 times/week, last feeding 24h before study initiation
- Health during acclimation (any mortality observed):
QUARANTINE
- Duration: 12d in quarantine
- Health/mortality: no external visible illnesses/0.25%
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96
- Remarks on exposure duration:
- h
Test conditions
- Hardness:
- 2.83 - 3.14 mmol/L
- Test temperature:
- 21 +/- 1°C
- pH:
- 7.39-7.49
- Nominal and measured concentrations:
- nominal: 0, 25, 50, 100, 200, 400 mg/L
measured: 0, 26.31/24.76, 47.78/48.84, 99.46/92.11, 205.48/204.58, 405.81/396.37 mg/L - Details on test conditions:
- TEST SYSTEM
- Material, size, headspace, fill volume: 10L
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): every 24h
- No. of organisms per vessel: 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tab water
Dilution water:
CaCl2: 2 mmol/L, MgSO4: 0.5 mmol/L, NaHCO3: 0.75 mmol/L, KCl: 0.075 mmol/L
The sum of the Calcium- and Magnesium ions in the dilution water is 2.5 mmol/L. The relation of Ca : Mg ions 4 : 1 and Na : K ions 10 : 1. The acid capacity of the solution is 0.8 mmol/L. The water will be aerated until oxygen saturation; afterwards the stock solutions will be mixed with 500mL dilution water.
Stock solutions:
(1): 0.5 g/L Chloroacetaldehyde dimethylacetal, (2): 1 g/L Chloroacetaldehyde dimethylacetal, (3): 2 g/L Chloroacetaldehyde dimethylacetal, (4) 4 g/L Chloroacetaldehyde dimethylacetal, (5): 8 g/L Chloroacetaldehyde dimethylacetal.
stock solution : dilution water is 1 : 20
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 light/8 dark
- Light intensity: 2000 lux - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- - Behavioural abnormalities: balance disorders in 1 fish (24h) and 2 fish (48h)
- Observations on body length and weight: normal: 2,8 cm in average and 0.35g in average
- Mortality of control: no
- Other adverse effects control: no
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Chloroacetaldehyde dimethylacetal was tested according to OECD Guideline 203 tested in zebra danio (Brachydanio rerio (new name: Danio rerio)). 2 out of 6 died, so the mortality was 1/3 at a concentration of 100 mg/l.
- Executive summary:
Chloroacetaldehyde dimethylacetal was tested according to OECD Guideline 203 tested in zebra danio (Brachydanio rerio (new name: Danio rerio)). The LD50 is > 100 mg/l.
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