Registration Dossier
Registration Dossier
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EC number: 217-090-4 | CAS number: 1738-25-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD 401 with acceptable restrictions mostly due to reduced reporting in times before GLP.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-dimethylaminopropiononitrile
- EC Number:
- 217-090-4
- EC Name:
- 3-dimethylaminopropiononitrile
- Cas Number:
- 1738-25-6
- Molecular formula:
- C5H10N2
- IUPAC Name:
- 3-(dimethylamino)propanenitrile
- Details on test material:
- - Name of test material (as cited in study report): N,N-Dimethyl-amino-propionitril
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 4640, 3160, 2150, 1470, 1000 µL/kg bw. (corresponding to ca. 3990 - 860 mg/kg bw; calculated with a density of 0.86 g/mL)
- No. of animals per sex per dose:
- 2 (in the lowest and highest dose) or 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 290 mg/kg bw
- Remarks on result:
- other: original value: 1500 µl/kg, calculated with a density of 0.86 g/mL
- Mortality:
- 1000 µL/kg bw: 0/4 animals
1470 µL/kg bw: 4/10 animals
all other animals treated with higher doses died - Clinical signs:
- Dyspnoe, stretch/bend convulsions, tremor, tonic-clonic convulsions, apathy, abdominal/ lateral position, unusual noises, reddish salivation, bad general state
- Gross pathology:
- Animals that died: acute heart dilatation, congestion, hyperemia, stomach dilatated, partly diffuse reddened
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
