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EC number: 228-412-8 | CAS number: 6262-07-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- 03.06.2016 – 15.06.2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- Council regulation (EC) No 440/2008
- Deviations:
- yes
- Remarks:
- See Any other information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- Adopted 27 July 1995
- Deviations:
- yes
- Remarks:
- See Any other information
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Remarks on result:
- not determinable
- Remarks:
- Estimation of Partition coefficient (log P) of the test substance Acid Black 26 was not possible determined by shake-flask method due to the fact that the sample is poorly soluble in n-octanol.
- Conclusions:
- Estimation of Partition coefficient (log P) of the test substance Acid Black 26 was not possible determined by shake-flask method due to the fact that the sample is poorly soluble in n-octanol.
- Executive summary:
The partition coefficient of the test substance Acid Black 26 was determined.
The procedure was performed according to method:
Method A.8. – Partition Coefficient, Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008.
OECD Test Guideline 107, Partition Coefficient (n-octanol/water): Shake Flask Method, Adopted 27 July 1995
Estimation of Partition coefficient (log P) of the test substance Acid Black 26 (CETA 466/15) was not possible determined by shake-flask method due to the fact that the sample is poorly soluble in n-octanol.
- Endpoint:
- partition coefficient
- Type of information:
- other: expert statement
- Adequacy of study:
- weight of evidence
- Study period:
- 01.07.2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- based on the recommendations of relevant guidelines and scientific opinion
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- Council regulation (EC) No 440/2008
- Deviations:
- not applicable
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- Adopted 27 July 1995
- Deviations:
- not applicable
- GLP compliance:
- no
- Key result
- Type:
- log Pow
- Remarks on result:
- other: < -2.5 based on expert statement
- Conclusions:
- Educated guess of Partition coefficient (log Pow) of the test substance, Acid Black 26, is: log Pow is lower than -2.5
- Executive summary:
Based on the new findings from previous studies of similar substances, it was decided that the determination of the partition coefficient made in Study No.: 446/15/47 Acid Black 26 – Partition Coefficient (n-octanol/water), VUOS-CETA , Report No.16-353, will be specified.
Alternatively the partition coefficient could be estimated on the base of the water solubility and on the base of solubility in octanol.
The water solubility of the test substance, Acid Black 26, established by the flask method is 67.3 g/L.
The test substance is practically insoluble in n-octanol.
Solubility of test substance in saturated n-octanol is under the limit of quantification – LOQ = 0.057 mg/L.
Based on this information the following Expert Statement is issued instead:
Educated guess of partition coefficient (log Pow) of the test substance, Acid Black 26, is lower than -2.5.
Educated guess of partition coefficient (log Pow) of the test substance is based on knowledge and experience from previous studies of similar substances.
Referenceopen allclose all
Estimation of partition coefficient was not determined by using the shake-flask method due to character of the test substance, Acid Black 26.
Description of key information
Estimation of Partition coefficient (log Kow) of the test substance Acid Black 26 was not possible determined by shake-flask method due to the fact that the sample is poorly soluble in n-octanol.
Educated guess of Partition coefficient (log Pow) of the test substance, Acid Black 26, is:
log Pow is lower than -2.5
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.5
Additional information
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