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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 9 - June 3, 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- RCC Ltd., Switzerland
Test material
- Reference substance name:
- A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate
- EC Number:
- 415-430-8
- EC Name:
- A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate
- Cas Number:
- 86403-32-9
- Molecular formula:
- C25H49NO2 C27H53NO2
- IUPAC Name:
- Reaction mass of 2,2,6,6-tetramethylpiperidin-4-yl hexadecanoate and 2,2,6,6-tetramethylpiperidin-4-yl octadecanoate
- Reference substance name:
- 86403-32-9
- Cas Number:
- 86403-32-9
- IUPAC Name:
- 86403-32-9
- Reference substance name:
- Reaction mass of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate
- IUPAC Name:
- Reaction mass of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate
- Details on test material:
- - Name of test material (as cited in study report): DASTIB 845 / SANDUVOR 845
- Substance type: organic
- Physical state: wax-like solid
- Analytical purity: 100% (pure waxy product)
- Lot/batch No.: 040698-27/V
- Expiration date of the lot/batch: December 31, 2001
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions: maximum 1 hour
- Storage condition of test material: at room temperature at about 20 °C, away from direct sunlight.
- Other: Not miscible with water at concentration above 500 ug/L.
Constituent 1
Constituent 2
Constituent 3
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
Any other information on results incl. tables
At the microscopic examination of the shape of the algal cells after 72 hours test period no difference was observed between the algae growing in the test medium and the algal cells in the control. Thus, the shape of the algal ceils growing at a loading rate of 100 mg/l was obviously not affected.
In the control the cell density has increased from nominal N = 1 x 10e4 cells/ml at the start of the test (0 hours) to N = 79.8 x 10e4 cells/ml (mean value) after 72 hours by a factor of approximately 80. Thus, the algal growth in the control was sufficiently high under the test conditions.
No remarkable observations were made concerning the appearance of test medium. The test medium was a clear solution throughout the entire test period.
At the start of the test the pH-value of control and test medium were in the range of pH 8.0-8.1. At the end of the test the pH in the test medium and the control had increased to pH 8.8
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item DASTIB 845 / SANDUVOR 845 had clearly no inhibitory effect on the growth (biomass and growth rate) of Scenedesmus subspicatus during the exposure period of 72 hours at the loading rate of 100 mg/l. Thus, this loading rate was determined as the 72-hour NOEC (highest concentration tested without toxic effects after a test period of 72 hours). The NOEC might even be higher, but loading rates in excess of 100 mg/l were not tested, according to the guidelines.
- Executive summary:
The influence of the test item DASTIB 845 / SANDUVOR 845 on the growth of the green algal species Scenedesmus subspicatus CHODAT was investigated in a 72-hour static test according to the Commission Directive 92/69/EEC, C.3, 1992, and the OECD Guideline No. 201, 1984.
A limit test was performed in accordance with the directive to demonstrate that the test item has no toxic effect on Scenedesmus subspicatus at a loading rate of 100 mg/l.
Due to the low water solubility of the test item a supersaturated suspension with a loading rate of nominal 100 mg/l was prepared by ultrasonic treatment for 15 minutes. No auxiliary solvent or emulsifier was used. This supersaturated suspension was stirred by a magnetic stirrer at 40°C in the dark over 24 hours to dissolve and disperse a maximum amount of the test item in the suspension. Then the suspension was filtered and the undiluted filtrate was used as the only test concentration. Additionally, a control was tested in parallel.
The mean analytically determined test item concentration in the analyzed test medium samples amounted to 0.15 mg/l at the start of the test. In this test medium, incubated under the test conditions during the test period (but without algae), the measured concentrations of DASTIB 845 / SANDUVOR 845 decreased below the limit of determination of the analytical method of 0.04 mg/l after 72 hours. The losses could be due to hydrolysis of the test item during the performance of the test. The total mean measured concentration (calculated as the average over the mean value at the start of the test and the value for the limit of determination) was about 0.1 mg/l. The biological results are related to the loading rate of 100 mg/l.
The test item DASTIB 845 / SANDUVOR 845 had clearly no inhibitory effect on the growth (biomass and growth rate) of Scenedesmus subspicatus during the exposure period of 72 hours at the loading rate of 100 mg/l. Thus, this loading rate was determined as the 72-hour NOEC (highest concentration tested without toxic effects after a test period of 72 hours). The NOEC might even be higher, but loading rates in excess of 100 mg/l were not tested, according to the guidelines.
The 72-hour LOEC (lowest concentration tested with toxic effects), respectively the 72-hour EC50, EC10 and EC90 for the algal biomass and the growth rate were clearly higher than the loading rate of 100 mg/l. These parameters could not be quantified due to the absence of a toxic effect of DASTIB 845 / SANDUVOR 845 up to the loading rate of 100 mg/l, and thus above the water solubility limit.
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