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Diss Factsheets
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EC number: 203-013-1 | CAS number: 102-20-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable, well documented publication, no guideline and no GLP study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Appraisal of Sensitizing Potential of Four Products By Maximization Testing
- Author:
- Kligman, A
- Year:
- 1 971
- Bibliographic source:
- Unpublished report to RIFM. Report 1805
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- After pre-testing the Maximization Test was conducted according to Journal of Investigative Dermatology 47 (5): 393-409 (1966).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenethyl phenylacetate
- EC Number:
- 203-013-1
- EC Name:
- Phenethyl phenylacetate
- Cas Number:
- 102-20-5
- Molecular formula:
- C16H16O2
- IUPAC Name:
- 2-phenylethyl phenylacetate
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not applicable
- Subjects:
- - Number of subjects exposed: 25
- Sex: male
- Age: Adult - Clinical history:
- - Other: Healthy males
- Controls:
- None
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Vehicle: Sodium lauryl sulfate
- Concentration: PPA, 2 %
Occlusive pretreatment: with 5 % aqueous sodium lauryl sulfate
Challenge application: with 10 % aqueous sodium lauryl sulfate
- Testing/scoring schedule: exposure time testing: patches were applied for five alternate-day 48 hour periods; Each test application was preceded by 24 h occlusive pretreatment of the patch site with 5 % aqueous sodium lauryl sulfate. Challenge patches were applied after a 10 day rest period, exposure time challenge patch: 48 h. Challenge applications were preceded by one-hour pretreatment with 10 % sodium lauryl sulfate.
EXAMINATIONS
- Grading/Scoring system: no data
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with negative reactions: 25
Applicant's summary and conclusion
- Conclusions:
- In a human maximization test no sensitizing potential of the test item could be found in 25 healthy adult males tested.
- Executive summary:
A Maximization Test was conducted on 25 healthy male humans to determine the contact sensitizing potential of the test item, applicated in diluted form of 2 %. The test substance was applied under occlusion to the volar forearms for five alternate-day 48 hour periods. The patch sites were pretreated for 24 hours with 5 % aqueous sodium lauryl sulfate under occlusion. Following a ten-day rest period, challenge patches were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by one-hour applications of 10 % aqueous sodium lauryl sulfate under occlusion. The challenge sites were read on removal of the patch and 24 hours thereafter. As no skin reactions were observed, the Maximization test results did not indicate a sensitizing effect of the test substance to the skin.
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