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EC number: 284-635-0 | CAS number: 84961-46-6 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinnamomum cassia, Lauraceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- May 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to a method similar to OECD 402, but was performed pre-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cinnamomum cassia, ext.
- EC Number:
- 284-635-0
- EC Name:
- Cinnamomum cassia, ext.
- Cas Number:
- 84961-46-6
- IUPAC Name:
- (2E)-3-(2-methoxyphenyl)prop-2-enal; (2E)-3-phenylprop-2-en-1-yl acetate; (2E)-3-phenylprop-2-enal
- Reference substance name:
- RIFM-72-4-79C
- IUPAC Name:
- RIFM-72-4-79C
- Details on test material:
- - Name of test material (as cited in study report): RIFM-72-4-79C, Cassia Oil
- Physical state: liquid (clear yellow)
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.16, 0.316, 0.63, 1.26 and 2.5 ml/kg
- Constant volume or concentration used: yes - Duration of exposure:
- Single application
- Doses:
- 168, 332, 600, 1323 and 2625 mg/kg (assuming density of 1.05 g/ml)
- No. of animals per sex per dose:
- 2 animals per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Mortality data were evaluated according to the Thompson Moving Average Method (Carrol S. Weil, Biometrics Vol.8 No.3 pp. 249-263, September 1952))
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 332 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 221 - 504
- Remarks on result:
- other: One out of two animals died on day 6
- Mortality:
- At lowest dosage level, no animals died. At second dosage level, 332 mg/kg bw, one animal died on day 6. At dosage level 662 mg/kg one animal died on day 1 and one on day 3. At the two highest dosage levels all animals died on day 1.
- Clinical signs:
- other: No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC)
- Conclusions:
- Under the conditions of this study, an LD50 of 332 mg/kg bw/day was determined for Cassia oil. Therefore, this substance is considered toxic in contact with skin and should be classified as such according to the criteria outlined in Annex I of CLP (Acute Tox. 3 / H311).
- Executive summary:
Ten albino rabbits were tested for acute dermal toxicity, according to a method similar to OECD 402. Five doses of Cassia oil were tested (168, 332, 600, 1323, 2625 mg/kg bw) using 2 animals per dose.
At the lowest dose no animals died. At the dose of 0.332 mg/kg bw 1 of two animals died and at the higher doses all animals died. The LD50 for Cassia oil was determined to be 332 mg/kg bw under the conditions of this study.
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