Registration Dossier
Registration Dossier
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EC number: 500-109-8 | CAS number: 43011-20-7
Endpoint summary
Administrative data
Description of key information
The substance is not classified for oral or dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- adequate
Additional information
BECKOPOX(TM) EH 694 was tested in an OECD Guideline 423 acute oral toxicity test under GLP conditions, at a limit dose of 2000 mg/kg bw. No deaths or adverse effects occurred, and the LD50 is greater than 2000 mg/kg bw. These results are consistent with the acute oral toxicity results of a chemically similar structure, ZAN 573 (CAS 63948 -88 -9).
These two substances are part of a chemical category of cyclic acid anhydrides based on common functional groups and similar breakdown products. Read-across from this category member, ZAN 573, is used to fill the acute dermal toxicity data requirement for BECKOPOX(TM) EH 694. The results of this study are that the substance is not toxic by the dermal route of administration.Justification for selection of acute toxicity – oral endpoint
experimental result
Justification for selection of acute toxicity – dermal endpoint
experimental result on a category member having a similar chemical structure
Justification for classification or non-classification
BECKOPOX(TM) EH 394 and structurally-similar members of the Selected Cyclic Acid Anhydride category show no evidence of acute toxicity by the oral or dermal routes of administration. The LD50 values are greater than 2000 mg/kg bw. The data does not meet the criteria for classification for acute toxicity according to Regulation EC No. 1272/2008.
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