Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-457-2 | CAS number: 13811-50-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Neither guideline nor GLP compliant study but nevertheless well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-divinylimidazolidin-2-one
- EC Number:
- 237-457-2
- EC Name:
- 1,3-divinylimidazolidin-2-one
- Cas Number:
- 13811-50-2
- Molecular formula:
- C7H10N2O
- IUPAC Name:
- 1,3-diethenylimidazolidin-2-one
- Details on test material:
- Name of the test substance used in the study report: N,N'-divinyl ethylene urea
Purity: 98.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean weight for male animals about 190 g, for female animals about 177 g.
Diet: The rats received Altromin-R supplied by Altrogge, Lage/Lippe, Germany, and water ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 30% strength aqueous suspension (weight/vol.) with carboxymethyl cellulose and 2 - 3 drops of Cremophor EL
- Details on oral exposure:
- The test concentration used was 30%.
- Doses:
- 3200, 4000, 5000, 6400, 8000 and 10000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 987 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 3200, 4000 and 5000 mg/kg: no deaths after 14 days
6400 mg/kg: 5/10 after 14 days
8000 mg/kg: 8/10 after 14 days
10000 mg/kg: 10/10 after 14 days - Clinical signs:
- other: 6400 and 3200 mg/kg: immediately after administration lateral-abdominal position in some animals, apathy and atonia. Surviving animals normal after 4 days. 8000 and 10000 mg/kg: immediately after administration staggering, abdominal position, dyspnea, int
- Gross pathology:
- Animals that died: general congestion, acute cardiac dilatation, loam-colored liver.
Sacrificed animals: forestomach callously thickened with adhesions to peritoneum.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
