Registration Dossier
Registration Dossier
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EC number: 434-630-6 | CAS number: 60372-77-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000-11-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- A guideline study with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- L.A.E.
Appearance: White solid
Batch: 2625
Expiry date: April 2001
Purity: 92-94% - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.43
- Temp.:
- 20 °C
- Remarks on result:
- other: No data on pH.
- Conclusions:
- The mean value for the partition coefficient from all determination was log Pow=1.43
- Executive summary:
The partition coefficient of Nα-Lauroyl-L-arginine ethyl ester monohydrochloride (LAE) was determined according to OECD 107 guideline and EU method A.8, the mean value from all determination was log Pow=1.43.
Reference
The analytical method was linear in the concentration range employed.
Description of key information
Key study: Test method OECD 107 and EU method A.8. GLP Study. The mean value for the partition coefficient of Nα-Lauroyl-L-arginine ethyl ester monohydrochloride (LAE) was log Pow=1.43
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.43
- at the temperature of:
- 20 °C
Additional information
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