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Diss Factsheets
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EC number: 252-346-9 | CAS number: 35074-77-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an occluded Patch test in humans no irritating or sensitising effects were noted in any of the probands. (IBT, 1978)
Additional information
A human patch test with repeated insult following the procedure of Draize, J. H. , Food Drug Cosmetic Law J., 10, 722 (1955) and Shelanski, H. A., and Shelanski, M. U., Proc Sci. Sect. Toilet Goods Assoc., 20, 46 (1953) was conducted (BASF, 1978). The test material was evaluated as a 10 % suspension in PEG-400. 50 male and female test subjects were exposed to 0.1 mL of the test substance per patch. 9 occlusive induction applications were applied to the intact skin of the upper back scapular area on three consecutive days each week. The patch was left in place for 23 hours. The skin sites were graded 30 to 60 minutes following the patch removal. 12 days after the last induction application, all panelists are exposed to a single occluded patch application of the test substance as during induction phase. The challenge patch is placed adjacent to but not in contact with the site of the induction applications. Grading for irritation was done 30 to 60 minutes after patch removal. Readings for sensitisation were done after 48 and 72 hours. One subject exhibited a slight reaction following the sixth patch application during the induction phase of the study. No further evidence of irritation was noted on this or any of the remaining 49 participants throughout the course of the study. There was no evidence of skin sensitisation noted in any of the test subjects following the challenge application.
This study was performed by a discredited CRO, therefore the quality is questionable. Nevertheless, the results are in line with the results obtained by recently performed state of the art in vitro testing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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