Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 256-220-4 | CAS number: 45294-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: OSHA Toxicity Screening Test. Limited documentation of the study. No detailed description of the test substance available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Guideline:
- other: OSHA Toxicity Screening Test
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- other: single dose
- Limit test:
- yes
Test material
- Reference substance name:
- Dodecyl pentadecyl methacrylate
- IUPAC Name:
- Dodecyl pentadecyl methacrylate
- Test material form:
- other: liquid
- Details on test material:
- No more data available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: no data
- Exposure chamber volume: 80 L
- Method of holding animals in test chamber: no data
- Source and rate of air: air flow: 4.12 L/min
- Method of conditioning air: The vapor was generated by bubbling a stream of clean, dry air (-40 °C dewpoint) through the undiluted test material in a gas washing bottle. The resulting air-vapor mixture was introduced into the exposure chamber.
- System of generating particulates/aerosols: -
- Method of particle size determination: no data
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: 25 °C, atmospheric pressure: 30.12 inches Hg - Duration of exposure:
- 1 h
- Concentrations:
- 1.42 mg/L air nominal concentration
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- > 1.42 mg/L air
- Based on:
- test mat.
- Remarks:
- nominal
- Exp. duration:
- 1 h
- Mortality:
- No mortality was observed (0/10 male rats)
- Body weight:
- Weight gain male: 102 g (within the normal limits).
- Gross pathology:
- No gross pathologic alterations observed at the end of 14-day observation period.
Any other information on results incl. tables
The average 2-week body weight gains were within the normal limits. Necropsy, performed on all rats at the end of the 14-day observation period, did not reveal any gross pathologic alterations.
Applicant's summary and conclusion
- Conclusions:
- In an acute inhalative toxicity study with Dodecyl pentadecyl methacrylate with male Charles River rats, an LC0 > 1.42 mg/L air (0/ 10 animals died) was observed.
- Executive summary:
In an acute inhalative OSHA toxicity screening test with Dodecyl pentadecyl methacrylate (purity: unknown), the test substance was administered for one hour in a concentration of 1.42 mg/L air to 10 male Charles river rats. There were no signs of intoxication reported within the 14-day observation period. No mortality, normal 2-week body weight gain. Necropsy, performed on all rats at the end of the study, did not reveal any gross pathologic alterations.
The determined LC0 was > 1.42 mg/L air in male Charles river rats.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.