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EC number: 700-300-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The procedures used in the study meet the requirements of the OECD Guideline for Testing of Chemicals No. 404, 1992.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- reaction mass of Lycopyl salt isomers
- IUPAC Name:
- reaction mass of Lycopyl salt isomers
- Details on test material:
- - Name of test material (as cited in study report): (2E,4E,6E)-(3,7,11-Trimethyl-dodeca-2,4,6,10-tetraenyl)-triphenyl-phosphonium acetate
- Physical state: clear yellow liquid
- Lot/batch No.: P19-39.5
- Storage condition of test material: In refrigerator at 2-8 °C, protected from light, covered with Nitrogen
- Other: Date of receipt 25 June 1996
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Farms (UK) Ltd., Froxfield
- Age at study initiation:
- Weight at study initiation:
- Housing: grid bottomed metal cages
- Diet (e.g. ad libitum): SQC standard rabbit pellets (Special Diet Services, Witham)
- Water (e.g. ad libitum): mains drinking water via automatic drinking system
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-24
- Humidity (%): 54-82
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- aliquot of 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- One hour after removal, similar observations were made after 24, 48 and 72 hours. As the skin reaction resulting from the treatment persisted after 72 hours, additional observations were made after 7 and 14 days.
- Number of animals:
- one in a pre-test
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm square
- Type of wrap if used: surgical lint
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gently cleansed with water
- Time after start of exposure: 4 hours
SCORING SYSTEM:
no erythema: 0; very slight erythema (barely perceptible): 1; well defined erythema: 2; moderate to severe erythema: 3; severe erythema (beet redness) to slight eschar formation (injuries in depth): 4; no oedema: 0; very slight oedema (barely perceptible): 1; slight oedema (edges of area well defined by definite raising): 2; moderate oedema (raised approximately 1 mm): 3; severe oedema (raised more than 1 mm and extending beyond area of exposure): 4
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- animal #1
- Time point:
- other: 72 hours
- Score:
- 5.5
- Reversibility:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test article may be seen as a severe irritant to the skin of the albino rabbit under the conditions of the study.
- Executive summary:
The purpose of the study was to assessthe degree of irritation produced by the test article, Ro 44 -9567/002, when applied to the intact skin of the albino rabbit. The procedures used meet the requirements of OECD Guideline number 404, adopted 17th July 1992.
In a preliminary test, a 0.5 mL aliquot of the test article was applied over a previously clipped area of the dorsal skin of one albino rabbit. The test article was held in contact with the skin, under semi-occlusive patch assembly, for a 4 hour period. The patch was then removed and the treated site gently cleansed with water. Skin reaction, i.e.erythema and eschar formation as well as oedema, was assessed after one, 24, 48 and 72 hours and 7 and 14 days.
The skin response at the treated site on this animal was apparent within one hour of patch removal and was characterised by well defined erythema and moderate to severe oedema which persistet at the 72 hour examination. At a subsequent examination, made 7 days after dosing, slight erythema and moderate oedema persisted and skin thickening was noted at the treated site. At the final examination, 14 days after dosing, erythema was still apparent although the oedema had subsided. The skin on the treated site was thickened and peeling.
Du to the severity of the skin response in this first rabbit, no further animals were dosed.
The primary irritation index, calculated from the scores obtained from one rabbit, was 5.5.
Accordingly, Ro 44 -9567/002 may be considered as a severe irritant when applied to the skin of the albino rabbit under the conditions of this study.
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