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EC number: 620-216-4 | CAS number: 298692-41-8
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-09-12 - 2007-04-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Remarks:
- Column: Reprosil-Pur C18 AQ; 125 x 3 mm ID, 5µm Mobile phase: A: water, B: methanol, A:B = 25:75 %(v/v); Elution: isocratic; Flow rate: 0.4 ml/min; temperature: room temperature; Sample loop volume: 20µl; Detection: RID (refractive index detector)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- isopropyl (diaminophosphoryl) carbamate
- Cas Number:
- 298692-41-8
- Molecular formula:
- C4H12N3O3P
- IUPAC Name:
- isopropyl (diaminophosphoryl) carbamate
- Details on test material:
- Purity: > 99%
Batch no.: S-9
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 0.5
- Temp.:
- 25 °C
- pH:
- 7
Any other information on results incl. tables
Table #: Partition coefficient n-octanol/water (HPLC Method)
Dead time t0/ min: |
||||
No. |
Reference substance |
Retention time (min) |
log k value |
log Pow value |
1 |
aniline |
2.579 |
-0.72 |
0.3 |
2 |
4 -acetylpyridine |
2.61 |
-0.70 |
0.5 |
3 |
nitrobenzene |
3.693 |
-0.15 |
1.9 |
4 |
benzene |
4.358 |
0.00 |
2.1 |
5 |
toluene |
5.527 |
0.19 |
2.7 |
6 |
ethylbenzene |
7.047 |
0.35 |
3.2 |
TS1 |
N-(Isopropoxycarbonyl) phosphoric acid triamide |
2.625 |
-0.68 |
0.5 |
TS = Test substance
Applicant's summary and conclusion
- Conclusions:
- The mean value for log Pow of the test item is 0.5.
- Executive summary:
The mean value for log Pow of the test item is 0.5.
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