Registration Dossier
Registration Dossier
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EC number: 201-143-3 | CAS number: 78-79-5
Endpoint summary
Administrative data
Description of key information
Additional information
Measured ecotoxicity results are available for isoprene for acute toxicity to fish and Daphnia and algal growth inhibition. The results are taken from OECD guideline studies conducted under GLP (HLS 2004) and are considered to be Klimisch 1 key studies. Additional data on isoprene have been identified from published review articles or websites. QSAR models have been used to provide further weight of evidence.
Additional ecotoxicity data have been identified for isoprene from several regulatory sources, including the OECD SIDS, the Japanese government website, the European Joint Research Committee and the US EPA’s High Production Volume program. Where data have been included, they have been assigned as Klimisch 4 because the original studies have not been reviewed. However, as the data are taken from regulatory sources, they are considered sufficiently robust to be used in the risk assessment. Where the regulatory documents have included a reliability score for data, this has been discussed in the individual records and taken into account in the selection of studies for determining the PNECs.
The acute effect concentrations are greater than the screening criteria and the chronic values are greater than the toxicity criterion stipulated in Annex XIII. Therefore, isoprene is not considered to be T based on aquatic toxicity data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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