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Diss Factsheets
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EC number: 202-525-2 | CAS number: 96-69-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 28 - April 4, 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although the study was quite old and not performed under GLP conditions, the described study method was comparable to OECD Guideline 404.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- not under GLP conditions, study dates 1986
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Name of test material (as cited in study report): Slz WX-R
- Analytical purity: 99.93%
- Lot/batch No.: 8623
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Japan Lab Animals Co., Ltd.
- Age at study initiation: not mentioned.
- Weight at study initiation: 2.05-2.47 kg
- Housing: individual metal mesh-bottomed suspenses cages.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 14 - 42 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 27
- Humidity (%): 45 - 75
- Air changes (per hr): not mentioned
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4.5, 24, 48, 72 hours and 1 week
- Number of animals:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- % coverage:
- Type of wrap if used: lint clot with PBS plus surgical tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, gauze with water
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize criteria
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4.5 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: (non) wounded test site
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: (non) wounded test site
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: (non) wounded test site
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 1.6
- Max. score:
- 2
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: non wounded test site
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: wounded test site
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 week
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: (non) wounded test site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4.5 h
- Score:
- 0.6
- Max. score:
- 1
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: non wounded test site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4.5 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: wounded test site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1.6
- Max. score:
- 2
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: (non) wounded test site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: (non) wounded test site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.6
- Max. score:
- 1
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: non wounded test site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 1 week
- Remarks on result:
- other: wounded test site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 week
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: (non) wounded test site
- Irritant / corrosive response data:
- 4.5 hours after the application of Slz WX-R, all of the cases (3 cases) showed erythema and edema in both the wounded site and the non-wounded site with a strength level of 1, at approximately the same extent for both findings. By 24 hours after application, the erythema had increased in intensity to a strength level of 2 in all of the cases, while the edema ranged in strength from 1 to 2. However, these local reactions gradually lessened, and by 1 week after application, all of the local reactions had disappeared.
The primary irritation rate that was calculated based on the above-noted results was 2.83, indicating that Slz WX-R will show moderate irritation of rabbit skin. - Other effects:
- none
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A study in 3 rabbits revealed that Slz WX-R 6 was moderately irritanting after 4-hour exposure. The study was not performed according to the general guidelines for acute dermal irritation/corrosion under GLP conditions, but was well performed and documented and as such considered reliable with minor restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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