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Diss Factsheets
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EC number: 940-514-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Pyrolysis light oil from waste plastics
- EC Number:
- 940-514-0
- Molecular formula:
- Not required for a UVCB-substance (mixture of multiple (>100) organic substances)
- IUPAC Name:
- Pyrolysis light oil from waste plastics
- Test material form:
- liquid: volatile
- Details on test material:
- Not given
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Species and strain: Rat Hsd: Sprague Dawley® SD®
Sex: Female
Colour: Albino
Supplier: Envigo RMS Spain S.L.
Health status: Specific Pathogen Free (SPF). The health monitoring report provided by the animal supplier will be stored at Vivotecnia.
Rationale for selection of species / strain: Rats are a suitable rodent species, acceptable to regulatory authorities as indicators of potential hazards, and for which extensive background data are available. Literature surveys of conventional LD50 tests showed that, although there is little difference in sensitivity between the sexes, in those cases where differences were observed females are generally slightly more sensitive.
Total number of animals: 6 animals to perform 3 dose steps.
Approx. age of the animals on arrival: 8 weeks old.
Animals per cage after distribution: 3
Bedding material: Sodispan SR-CHOPO-T.
Change of cages: At least once a week
Inclusion criteria on arrival: Prior to inclusion in the study, animals were subjected to individual veterinary examination. Only animals without clear visible sign of illness that may interfere with the study were included.
Acclimatisation period and distribution: 5 days. Animals were randomly distributed by means of the body weight stratification method. 20% of the mean body weight (for the first defined dose at the beginning of the study and further dose steps).
Animal identification: Digit ink marks.
ENVIRONMENTAL CONDITIONS
Light cycle: 12:12
Temperature / Relative humidity: 19 - 25ºC / 30 – 70%
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 6 animals to perform 3 dose steps.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 30 minutes, 2h, and 4h post-administration and once daily thereafter during the 14-day observation period
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs and body weight
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No observed
- Clinical signs:
- other: No observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 is > 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.