Registration Dossier
Registration Dossier
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EC number: 203-614-9 | CAS number: 108-77-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: EEC 84/449/EEC
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,4,6-trichloro-1,3,5-triazine
- EC Number:
- 203-614-9
- EC Name:
- 2,4,6-trichloro-1,3,5-triazine
- Cas Number:
- 108-77-0
- Molecular formula:
- C3Cl3N3
- IUPAC Name:
- 2,4,6-trichloro-1,3,5-triazine
- Details on test material:
- Cyanuric chloride, purity > 95%.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- weight 3.6-4.0 kg
age 28-38 weeks
Test system
- Type of coverage:
- occlusive
- Vehicle:
- other: polyethylene glycol
- Amount / concentration applied:
- Test 1: Application of 0.3 g test substance, moistened with polyethylene glycol on the skin (2.5 X 2.5 cm) under occlusion for 24 h.
Test 2: Daily application of 2% or 10% suspension in polyethylene glycol on the internal area of the ear for 10 days. - Duration of treatment / exposure:
- Test 1: 24 h
Test 2: daily application - Observation period:
- Test 1: Skin observations at 1, 24, 48 and 72 h and daily until day 29.
Test 2: Daily skin observation (alternating between just before and just after application) - Number of animals:
- 6 males (test 1), 4 males/group (test 2).
Results and discussion
Any other information on results incl. tables
Test 1The results of a test with abraded skin were not included.
Animal |
1 |
2 |
3 |
4 |
5 |
6 |
Time
|
E O |
E O |
E O |
E O |
E O |
E O |
1 h |
4 1 |
2.5 0 |
3-4 1 |
3-4 1 |
3 0 |
3 0 |
24 h |
4 1 |
2.5 0 |
3-4 1 |
3-4 1 |
3 0 |
3 0 |
48 h |
3 0 |
4 0 |
3 0 |
4 0 |
2.5 0 |
3 0 |
72-96 h |
n.d. n.d. |
n.d. n.d. |
n.d. n.d. |
n.d. n.d. |
n.d. n.d. |
n.d. n.d. |
5 days |
2 0 |
3 0 |
4 0 |
4 0 |
3 0 |
4 0 |
6-7 days |
1 0 |
2 0 |
3 0 |
3 0 |
2.5 0 |
3 0 |
8 days |
0 0 |
0 0 |
0 0 |
2 0 |
2 0 |
0 0 |
9 days |
0 0 |
0 0 |
0 0 |
3 0 |
2 0 |
1 0 |
10-11 days |
0 0 |
0 0 |
0 0 |
1 0 |
1 0 |
0 0 |
12-29 days |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
E=erythema O=oedema
Test 2No oedema was seen, erythema scores are presented in the table below.
Dose |
2% |
10% |
||||||
Animal |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
Day |
|
|
|
|
|
|
|
|
1 |
0 |
0 |
0 |
0 |
+ |
+ |
+ |
+ |
2 |
0 |
0 |
0 |
0 |
+ |
+ |
? |
+ |
3 |
0 |
0 |
0 |
0 |
+ |
+ |
? |
+ |
4 |
0 |
0 |
0 |
0 |
++ |
+ |
++ |
+ |
5 |
0 |
0 |
0 |
0 |
++ |
++ |
++ |
+ |
6-10 |
0 |
0 |
0 |
0 |
++ |
++ |
++ |
++ |
0= no erythema += slight ++ well-defined to moderate ? not indicated
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- Irritating (based on the results of test 1).
- Executive summary:
In an skin irritation study, the cyanuric chloride was found to be irritating.
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