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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP compliance

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Qualifier:
according to guideline
Guideline:
other: EEC 84/449/EEC
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-trichloro-1,3,5-triazine
EC Number:
203-614-9
EC Name:
2,4,6-trichloro-1,3,5-triazine
Cas Number:
108-77-0
Molecular formula:
C3Cl3N3
IUPAC Name:
2,4,6-trichloro-1,3,5-triazine
Details on test material:
Cyanuric chloride, purity > 95%.

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
weight 3.6-4.0 kg
age 28-38 weeks

Test system

Type of coverage:
occlusive
Vehicle:
other: polyethylene glycol
Amount / concentration applied:
Test 1: Application of 0.3 g test substance, moistened with polyethylene glycol on the skin (2.5 X 2.5 cm) under occlusion for 24 h.
Test 2: Daily application of 2% or 10% suspension in polyethylene glycol on the internal area of the ear for 10 days.
Duration of treatment / exposure:
Test 1: 24 h
Test 2: daily application
Observation period:
Test 1: Skin observations at 1, 24, 48 and 72 h and daily until day 29.
Test 2: Daily skin observation (alternating between just before and just after application)
Number of animals:
6 males (test 1), 4 males/group (test 2).

Results and discussion

Any other information on results incl. tables

Test 1The results of a test with abraded skin were not included.

Animal

1

2

3

4

5

6

Time

 

E         O

E         O

E         O

E         O

E         O

E         O

1 h

4           1

2.5        0

3-4       1

3-4      1

3           0

3          0

24 h

4           1

2.5        0

3-4       1

3-4      1

3           0

3          0

48 h

3           0

4           0

3           0

4          0

2.5        0

3          0

72-96 h

n.d.      n.d.

n.d.      n.d.

n.d.      n.d.

n.d.      n.d.

n.d.      n.d.

n.d.      n.d.

5 days

2           0

3            0

4           0

4           0

3           0

4           0

6-7 days

1           0

2           0

3           0

3           0

2.5        0

3           0

8 days

0           0

0           0

0           0

2           0

2           0

0           0

9 days

0           0

0           0

0           0

3           0

2           0

1           0

10-11 days

0           0

0           0

0           0

1           0

1           0

0           0

12-29 days

0           0

0           0

0           0

0           0

0           0

0           0

E=erythema O=oedema

Test 2No oedema was seen, erythema scores are presented in the table below.

Dose

2%

10%

Animal

1

2

3

4

5

6

7

8

Day

 

 

 

 

 

 

 

 

1

0

0

0

0

+

+

+

+

2

0

0

0

0

+

+

?

+

3

0

0

0

0

+

+

?

+

4

0

0

0

0

++

+

++

+

5

0

0

0

0

++

++

++

+

6-10

0

0

0

0

++

++

++

++

0= no erythema += slight ++ well-defined to moderate ? not indicated

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information
Conclusions:
Irritating (based on the results of test 1).
Executive summary:

In an skin irritation study, the cyanuric chloride was found to be irritating.