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Diss Factsheets
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EC number: 421-880-6 | CAS number: 201792-73-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Ames test: Positive
Ames test NR: nitroreductase activity, plays a major role in the mutagenic properties of the substance
OECD Guideline 476 (In Vitro Mammalian Cell Gene Mutation Test): negative
OECD Guideline 487 (In vitro Mammalian Cell Micronucleus Test): negative
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Genetic toxicity in vivo
Description of key information
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test): negative
OECD Guideline 489 (In vivo Mammalian Alkaline Comet Assay), similar substance 2: testing proposal
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Two Ames tests are available on Acid Black 210; one test (Stahl, 1996) was performed on strain: TA100, TA 98, TA1535, TA 1537, WP2P and WP2PuvrA and one test (ABK210 Consortium, 2020) was performed on strain TA98, TA100, TA102, TA1535, TA1537 and the nitroreductase deficient strains, TA 98NR and TA 100 NR.
Both test were disrgegarded for the reason discussed in the expert statements.
Therefore, two expert assessments were added as Weight of evidence, in order to analyse all the results of the Ames test, considering also the structural and mechanicistic evaluations.
One In vitro mammalian cell micronucleus test following OECD 487 (Consortium, 2010) and one gene mutation in vitro, following OECD 476 (Stahl, 1996) are available and both test show negative results.
Moreover, also an in vivo test, following OECD 474 is available on Acid Black 210 (Stahl, 1996) and the results are negative.
Finally, a testing proposal for OECD 489, comet assay has been proposed on similar substance 2.
Therefore the substance is consider not mutagenic for the time being. the classification will be confirm with the results of the comet assay.
Short description of key information:
not mutagenic
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Classification for mutagenicity is warranted for substances which cause concern for humans owing to the possibility that they may induce heritable mutations in the germ cells of humans
The classification in Category 2 is based on:
— positive evidence obtained from experiments in mammals and/or in some cases
from in vitro experiments, obtained from:
— somatic cell mutagenicity tests in vivo, in mammals; or
— other in vivo somatic cell genotoxicity tests which are supported by positive results from in vitro mutagenicity assays.
Based on the negative results of the in vivo tests on the similar substance, OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test) no classification for mutagenicity is applied following Regulation 1272/2008.
This classification will be confirmed after the results of the OECD Guideline 489 (In vivo Mammalian Alkaline Comet Assay).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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