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Diss Factsheets
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EC number: 639-566-4 | CAS number: 165184-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 7 and 17 December 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to Annex VI directive 92/69/EEC Part B Method B.4 and under GLP Guidelines.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
Test material
- Details on test material:
- - Name of test material (as cited in study report): Hexyl Cinnamic Aldehyde
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 12 to 14 weeks old
- Weight at study initiation: 2.8 to 3.2 Kg
- Housing: housed individually in metal cages with perforated floors.
- Diet (e.g. ad libitum): standard laboratory diet SDS Stanrab (P) Rabbit Diet provided ad libitum
- Water (e.g. ad libitum): provided ad libitum
- Acclimation period: no information
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 ºC
- Humidity (%): 30-70%
- Air changes (per hr): 19 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours of artificial light in each 24 hours period
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 11 days
- Number of animals:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: 100 mm X 100 mm
- Type of wrap if used: "Elastoplast" elastic adhesive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water (30 ºC to 40 ºC)
- Time after start of exposure: 4 hours. The treated area was blotted dry with absorbent paper
SCORING SYSTEM:
Erythema and eschar formation
No erythema: 0
Very slight erythema: 1
Well-defined erythema: 2
Moderate to severe erythema: 3
Severe erythema to slight eschar formation: 4
Oedema formation
No oedema: 0
Very slight oedema: 1
Slight oedema: 2
Moderate oedema: 3
Severe oedema: 4
Any other lesion not covered by this scoring system, was described.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- mean individual score
- Time point:
- other: overall 24-48-72h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- mean individual score
- Time point:
- other: overall 24-48-72h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- mean individual score
- Time point:
- other: overall 24-48-72h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- mean individual score
- Time point:
- other: overall 24-48-72h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- mean individual score
- Time point:
- other: overall 24-48-72h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- mean individual score
- Time point:
- other: overall 24-48-72h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Irritant / corrosive response data:
- See Table 7.3.1/1
- Other effects:
- There were no signs of toxicity or ill health in any rabbit during the observation period
Any other information on results incl. tables
Table 7.3.1/1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Rabbit number and sex | E = Erythema O = Oedema |
Day | ||||||||||
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | ||
2791 male | E | 2 | 2 | 2 | 2 | a3 | a3 | a2 | a1 | a1 | a1 | 0 |
O | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 0 | |
2792 male | E | 2 | 2 | 2 | 2 | a2 | a2 | a1 | a1 | a1 | a1 | 0 |
O | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | |
2793 male | E | 2 | 2 | 2 | 2 | 2 | a2 | a0 | a0 | a0 | a0 | 0 |
O | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | |
a Desquamation of the stratum corneum |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information R38 Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions HCA is classified as irritating to skin (Xi; R38) according to the Directive 67/548/EEC but is not classified under the Regulation (EC) No. 1272/2008 (CLP).
- Executive summary:
In a dermal irritation study performed according to the EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) and in compliance with GLP, 3 male New Zealand White rabbits, were exposed to 0.5 mL of undiluted Hexyl cinnamic aldehyde (HCA). Test sites were covered with a semi-occlusive dressing for 4 hours. Animals were then observed for 11 days.
The mean individual scores calculated within 3 scoring times (24, 48 and 72 hrs) were 2/2/2 for erythema and 1.33/1.67/1.67 for edema. All the reactions were fully reversible within 11 days.
Under the test conditions HCA is classified as irritating to skin (Xi; R38) according to the Directive 67/548/EEC but is not classified under the Regulation (EC) No. 1272/2008 (CLP).
This study is considered as acceptable and satisfies the requirement for skin irritation endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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