Chloroacetone

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1996-05-14 to 1996-08-30

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Calculation of the degradation rate is done with values in the wrong units. This leads to completely wrong degradation rates.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1996

Report date:

1996

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Chloroacetone

EC Number:

201-161-1

EC Name:

Chloroacetone

Cas Number:

78-95-5

Molecular formula:

C3H5ClO

IUPAC Name:

1-chloropropan-2-one

Details on test material:

- Name of test material (as cited in study report): Monochloracetone
- Physical state: liquid
- Analytical purity: 96.18 %
- Impurities (identity and concentrations): 1,3-Dichloracetone (0.5%); 4-Methylpent-3-en-2-on (1%); 1,1-Dichloracetone (3%)
- Lot/batch No.: 603015
- Expiration date of the lot/batch: March 12, 1997
- Stability under test conditions: room temperature, dark
- Storage condition of test material: moderat stable

Study design

Oxygen conditions:

aerobic

Inoculum or test system:

sewage, predominantly domestic (adaptation not specified)

Details on inoculum:

- Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): municipal waste water treatment plant Bitterfeld-Wolfen

Duration of test (contact time):

28 d

Initial test substance concentration

Initial conc.:

2 mg/L

Based on:

formulation

Parameter followed for biodegradation estimation

Parameter followed for biodegradation estimation:

O2 consumption

Reference substance

Reference substance:

acetic acid, sodium salt

Results and discussion

% Degradation

% Degradation 1

Parameter:

% degradation (O2 consumption)

Value:

59.9

Sampling time:

28 d

Remarks on result:

other: re-evaluated by the applicant

% Degradation 2

Parameter:

% degradation (O2 consumption)

Value:

0

Sampling time:

28 d

Remarks on result:

other: degradation not correctly calculated

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Interpretation of results:

other: not readily biodegradable

Conclusions:

Monochloroaceton was not readily biodegradable under the conditions of the test. The biodegradation rate was 59.9 %

Executive summary:

Monochloroacetone was examined for ready biodegradability according OECD Guideline 301D. The Theoretical oxygen demand (ThOD) was not correctly calculated in the original report and expressed in units that led to a completely wrong value for the degradation rate of the test substance. The ThOD must have been 1.21 mg/mg as recalculated with the formula given in the OECD Guidelines. The degradation rates in Table 3 of the test report were therefore recalculated with the correct ThOD. Monochloroaceton was not readily biodegradable under the conditions of the test. The biodegradation rate was 59.9 %. The procedure control worked as expected and the toxicity control did not indicate toxicity to suldge.