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EC number: 201-202-3 | CAS number: 79-39-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LC50 fish (96h): > 100 mg/l
EC50 daphnia (48h): > 1000 mg/l
NOEC daphnia (21d): > 100 mg/l
ErC50 algae (72h): > 1000 mg/l
NOErC algae (72h): 1000 mg/l
EC50 microorganisms (3h): 995 mg/l
Additional information
Acute aquatic tests are available for all three trophic levels. Chronic data are available with Daphnia magna and algae.
Methacrylamide is not toxic to aquatic organisms and plants.
Summaries:
In a 96-h acute toxicity study, Medaka (Oryzias latipes) were exposed to methacrylamide at nominal concentrations of > 100 mg/l without solvent under semistatic conditions. The 96-h LC50 was > 100 mg/l.
Based on the results on this study, methacrylamide would be classified as not acute toxic to fish in accordance with th classification CLP regulation.
This toxicity study is classified as acceptable and satifies the guideline for Fish, acute toxicity study (OECD 203)
LC50: > 100 mg/l measured/nominal
The 48–hr-acute toxicity of methacrylamide to Daphnia magna was studied under static conditions. Daphnids were exposed to control and test item at nominal/measured concentration of 1000 mg/l for 48 hr. Immobilization was observed daily. The 48–hour EC50was > 1000 mg a.i./L. The 48– hr NOEC based on immobilization effects was 1000 mg a.i./L.
EC50 (48hr): > 1000 mg/l
In a 72-hour acute toxicity study, the cultures of Pseudokirchneriella subcapitata, strain ATCC-22662 were exposed to control and test item at nominal/measured concentrations of 1000 mg a.i./L in accordance with the Algae, Growth Inhibition Test, OECD 201 The NOEC and ErC50values based on growth inhibition were 1000 mg/l and > 1000 mg a.i./L, respectively. The % growth inhibition in the treated algal culture as compared to the control ranged from -2.08 to 1.59
There were no compound related phytotoxic effects.
The 21-day-chronic toxicity of methacrylamide to Daphnia magna was studied under static renewal conditions. Daphnids were exposed to control and test chemical at nominal/measured concentrations of 100 mg a.i./L. The 21 day LC50/EC50based on mortality/sublethal effect was > 100 mg a.i./L. The 21-day NOEC based on sublethal effect was >100 mg a.i./L. The sublethal effects included were reproduction. Production of offsprings in the treated groups indicated that methacrylamide did not have an effect on the reproduction at concentrations greater than > 100 mg a.i./L.
In a vaild respiration inhibition test with activated sludge (OECD 209) Methacrylamide was tested at concentrations of31.3, 62.5, 125, 250, 500, 1000 and 2000 mg/l (nominal concentrations). EC50 (3h) was 995 mg/l, EC10 (3h) was 37 mg/l.
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