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Diss Factsheets
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EC number: 403-730-1 | CAS number: 2687-96-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: considered as Category 1C (Corrosive)
Eye irritation: considered as Category 1 (Irreversible effects on the eye)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation/corrosion
Four studies were available:
1) A DOT skin corrosion study (Nitka, 1990) is available which is key study.
The substance was administered neat to unabraded skin for 4 hours and clear signs of corrosion were shown in all animals.
2) A primary skin irritation study (Romanelli, 1990) is available which is supporting study.
The substance was administered neat to skin for 24 hours, one site was left intack and the other received minor epidermal abrasions . The substance was clearly a dermal irritant and showed signs indicating skin corrosion.
3) A primary dermal irritation study (Lewis, 1978) is available which is supporting study.
The substance was administered neat to both abraded and unabraded skin for 24 hours. The substance was clearly a dermal irritant and showed signs indicating skin corrosion. This study clearly supports the findings of the key study.
4) A primary dermal irritation study (Nitka, 1986) is available which is supporting study. This study showed slightly irritating when used a 2% aqueous suspension.
Eye irritation
An eye irritation toxicity studies with rabbit (Nitka, 1986) which run on analog substance N-(n-octyl)-2-pyrrolidinone (2687-94-7) was conducted according to modification of that described by J.H. Draize. Key study.
This study showed that the test substance is a severe ocular irritant to rabbits under conditions of this test.
A primary ocular irritation study (Nitka, 1986) is available which is supporting study. This study showed the test substance is not irritating when used a 2% aqueous suspension.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Skin irritation/corrosion: A primary skin irritation study give a corrosive result after 4 hours of exposure (Nitka, 1990). Classification with Category 1A and 1B is not considered justifiable as according to Regulation (EC) No. 1272/2008 Tables 3.2.1 this is only applicable where exposure time is <=3 minutes (Category 1A) and >3 minutes -<= 1 hour (Category 1B). The shortest actual exposure duration was 4 hours (Nitka, 1990).
Serious eye damage/eye irritation: At least one animal exhibited effects on the cornea (6 of 6 animals), iris (5 of 6 animals) and conjunctiva (5 of 6 animals) after 21 day (Nitka, 1986, on an analog substance).
Therefore in accordance with Regulation (EC) No. 1272/2008 Tables 3.2.1 & Section 3.3.2.4 the substance is classified as "Category 1C (Corrosive)" for the skin corrosion/irritation endpoint and Category 1 for the serious eye damage/eye irritation endpoint.
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