Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-953-2 | CAS number: 112-27-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The Excretion and Metabolism of Triethylene Glycol
- Author:
- Herbert McKennis, Jr., Robert A. Turner, Lennox B. Turnbull, and Edward R. Bowman
- Year:
- 1 962
- Bibliographic source:
- Toxicology and Applied Pharmacology 4, 411-431
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- Principles of method if other than guideline:
- no information available about testing method
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-(ethylenedioxy)diethanol
- EC Number:
- 203-953-2
- EC Name:
- 2,2'-(ethylenedioxy)diethanol
- Cas Number:
- 112-27-6
- Molecular formula:
- C6H14O4
- IUPAC Name:
- 2-[2-(2-hydroxyethoxy)ethoxy]ethan-1-ol
- Test material form:
- liquid
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- 1 female rabbit was given a single dose of 200 mg/kg TEG via stomach tube. In a similar experiment, another animal received a 2000 mg/kg dose orally for 3 consecutive days. Urine from the dosed animals was subsequently collected for 24 hours (from the animal receiving 200 mg/kg), and during the 3 days of dosing and a subsequent 3-day period (from the animal receiving 2000 mg/kg), respectively.
- Duration and frequency of treatment / exposure:
- 24 hours
Doses / concentrationsopen allclose all
- Dose / conc.:
- 200 mg/kg bw (total dose)
- Remarks:
- Low dose rabbits
- Dose / conc.:
- 2 000 mg/kg bw (total dose)
- Remarks:
- High dose rabbits
- No. of animals per sex per dose / concentration:
- 2 female rabbits
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
Following the single oral administration of 200 mg/kg, 34.3% of the dose was excreted in the urine as unchanged TEG.
The rabbit dosed with 2000 mg/kg TEG excreted 28.3% of the dose amount in the urine as unchanged TEG, while 35.2% of the administered dose were recovered as a hydroxyacid form of TEG.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: In discussing treatment of TEG poisoning, it was stated that TEG is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. TEG metabolism by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole. In discussing treatment of TEG poisoning, it was stated that TEG is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. TEG metabolism by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole or ethanol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.