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EC number: 219-785-8 | CAS number: 2530-85-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-05-27 to 2002-06-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Control and nominal concentration of 100 mg/l
- Sampling method: Duplicate samples of fresh (Control and 100 mg/l treatment excluding Daphnids) and old (Control and 100 mg/l treatment including Daphnids) test media were taken.
- Sample storage conditions before analysis: Samples were immediately frozen to approximately -20ºC. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The single test medium concentration of 100 mg/l was prepared by dissolving 30 mg of the test substance in 300 ml of water by stirring for 30 minutes at room temperature.
- Controls: Dilution water - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain: Clone 5
- Source: The University of Sheffield, U.K.
- Age at study initiation (mean and range, SD): 6 - 24 hours
- Method of breeding: Parthenogenetic reproduction
- Feeding during test: None
ACCLIMATION
- Acclimation conditions (same as test or not): yes
- Type and amount of food: not reported
- Feeding frequency: not reported
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg/l (as CaCO3)
- Test temperature:
- 21ºC
- pH:
- 7.8 - 8.0
- Dissolved oxygen:
- 8.0 - 8.4
- Nominal and measured concentrations:
- Nominal concentrations: Control and 100 mg/l
Measured concentration in 100 mg/l treatment at start of test: 78 mg/l
Measured concentration in 100 mg/l treatment at end of test: 99 mg/l
Results based on measured silicon concentrations - Details on test conditions:
- TEST SYSTEM
- Test vessel: Beakers
- Type: closed
- Material, size, headspace, fill volume: glass, 100 ml, 50 ml headspace (approx.) and 50 ml fill volume
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 1 daphnid/5 ml of test medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted fresh water prepared by mixing analar grade salts into purified water.
- Alkalinity: 0.8 mmol
- Ca/mg ratio: 4:1
- Conductivity:
- Culture medium different from test medium: no
- Intervals of water quality measurement: daily
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16/8., light/dark
- Light intensity: 550-690 Lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilization after 24 and 48 h.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit test at 100 mg/l
- Justification for using less concentrations than requested by guideline: Range-finding study result
- Range finding study
- Test concentrations: not reported
- Results used to determine the conditions for the definitive study: not reported - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: none
- Mortality of control: 0
- Other adverse effects control: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: none - Reported statistics and error estimates:
- There were no toxic effects in the test and therefore statistical analysis of the results was not required.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-h EC50 value of >100 mg/l and NOEC of =100 mg/l have been determined for the effects of the test substance on mobility of Daphnia magna. It is likely that the test organisms were exposed primarily to the hydrolysis products of the substance.
Reference
No toxic effects were observed in the test.
Description of key information
48-hour EC50 >100 mg/l (nominal, highest concentration tested) (EU C.2), Daphnia magna. The EC50 is equivalent to >83 mg/l when expressed in terms of the silanol hydrolysis product, 3-(trihydroxysilyl)propyl methacrylate.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 83 mg/L
Additional information
A 48-hour EC50 value of >100 mg/l (nominal, highest concentration tested) has been determined for the effects of the registration substance, 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0, EC 219-785-8), on the mobility of Daphnia magna (Momentive, 2002b). Analysis of the tested substance by atomic absorption spectrophotometry was conducted, which does not differentiate between the parent substance and the silanol hydrolysis product. The mean measured concentrations did not deviate by more than 20% when compared to nominal concentrations. The test was conducted according to EU Method C.2 and in compliance with GLP. In view of the test media preparation method and exposure regime, it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance, 3-(trihydroxysilyl)propyl methacrylate and methanol.
The results may be expressed in terms of concentration of the silanol hydrolysis product, 3-(trihydroxysilyl)propyl methacrylate, by applying a molecular weight correction: (MW of silanol = 206.27 / MW of parent = 248.35) * >100 = >83 mg/l.
This value is supported by two short-term aquatic invertebrate toxicity studies. A reliable limit test was conducted at a concentration of 876 mg/l to Daphnia magna, for 48-hours' exposure, and no effects on mobility were observed (Evonik, 1995). Another study reported an EC50 value of 399 mg/l for Daphnia magna, however the reliability of the results could not be determined because there was insufficient information in the source (Momentive, 1997b).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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