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EC number: 231-835-0 | CAS number: 7758-16-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 06 October 2009 and 04 December 2009.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 2009-09-15 Date of Signature: 2009-11-26
- Type of method:
- flask method
- Remarks:
- EXAMPLE: The determination was carried out using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.
- Water solubility:
- 170 g/L
- Temp.:
- 20 °C
- pH:
- >= 3.8 - <= 3.9
- Details on results:
- Please see section Remarks on results including tables and figures.
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the test material has been determined to be 170 g/l of solution at 20.0 ± 0.5°C in un-buffered glass double-distilled water, resulting in sample solution pH’s of approximately 3.8 to 3.9.
This study is conducted according to the appropriate guidelines (EU ) and under the conditions of GLP and therefore the study is considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement as a key study for this endpoint. - Executive summary:
Method
The determination was carried out using the flask method, Method A6 Water Solubility ofCommissionRegulation (EC) No 440/2008 of 30 May 2008.
Conclusion
The ion chromatography method applied directly quantified the dissolved pyrophosphate content of each sample solution and these have been corrected to equivalent test material concentrations based on the theoretical pyrophosphate content of the test material.
The water solubility of the test material has been determined to be 170 g/l of solution at 20.0 ± 0.5°C in un-buffered glass double-distilled water, resulting in sample solution pH’s of approximately 3.8 to 3.9.
The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the solubility of the test material (range 169 to 173 g/l).
The solubility of the test material over the environmentally relevant pH range of 4 to 9 gave solubility results and final solution pH’s similar to those obtained using unbuffered water (range 172 to 175 g/l). Thus, it can be anticipated that the water solubility of the test material over the pH range 4 to 9 would be constant, essentially due to the low buffering activities seen in the environment.
Reference
Results
Preliminary test
The preliminary estimates of water solubility in un-buffered glass double-distilled water, pH 4 and pH 9 buffered solutions are shown in the following table:
Sample Number |
Test Media |
Time shaken at ~ 30ºC (hours) |
Time equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
A |
glass double - distilled water |
19 |
3 |
175 |
3.66 |
B |
pH 4 buffer |
19 |
3 |
174 |
3.65 |
C |
pH 9 buffer |
19 |
3 |
172 |
3.67 |
Definitive test
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Solution |
Mean peak area |
Standard 29.9 mg/l |
4.550 |
Standard 29.9 mg/l |
4.504 |
Sample 1A |
4.053 |
Sample 1B |
4.049 |
Sample 2A |
3.971 |
Sample 2B |
3.992 |
Sample 3A |
4.067 |
Sample 3B |
4.094 |
Standard 29.9 mg/l |
4.562 |
Standard 29.9 mg/l |
4.519 |
Sample 4A |
4.010 |
Sample 4B |
4.040 |
Sample 5A |
4.083 |
Sample 5B |
4.149 |
The concentration (g/l) of test material in the sample solutions is shown in the following table:
Sample Number |
Test Media |
Time shaken at ~ 30ºC (hours) |
Time equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
glass double-distilled water |
24 |
20.0 |
171 |
3.84 |
2 |
glass double-distilled water |
48 |
20.0 |
168 |
3.82 |
3 |
glass double-distilled water |
72 |
20.0 |
172 |
3.92 |
4 |
glass double-distilled water |
72 |
10.0 |
169 |
3.93 |
5 |
glass double-distilled water |
72 |
30.0 |
173 |
3.74 |
Overall result (mean of samples 1 to 3): 170 g/l at 20.0 ± 0.5°C
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 50 mg/l (as pyrophosphate anion). This was satisfactory with a correlation coefficient of 0.999 being obtained.
Description of key information
The water solubility of disodium dihydrogenpyrophosphate was determined according to EU Method A.6 (Water solubility) and under the conditions of GLP.
Key value for chemical safety assessment
- Water solubility:
- 170 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material has been determined to be 170 g/l of solution at 20.0 ± 0.5°C in un-buffered glass double-distilled water, resulting in sample solution pH’s of approximately 3.8 to 3.9.
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