Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-854-4 | CAS number: 111-29-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity of 1,5-pentanediol in vitro was analyzed in a study performed according to OECD guideline 471 and EU method B.13/14 (BASF, 1992). Bacteria S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 were treated with concentrations of 20, 100, 500, 2500 and 5000 ug/plate with and without metabolic activation by Aroclor 1254 pretreated rat liver S9 mix. With both used methods, the plate incorporation and the preincubation methods, no genetic toxicity was found.
The substance 1,5-Pentanediol was assessed for its potential to induce gene mutations at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus in Chinese hamster ovary (CHO) cells in vitro. The negative controls gave mutant frequencies within the range expected for the CHO cell line. Both positive control substances, ethyl methanesulfonate (EMS) and 7,12-dimethylbenz[a]-anthracene (DMBA), led to the expected statistically significant increase in the frequencies of forward mutations. In this study, in all experiments in the absence and the presence of metabolic activation no relevant cytotoxicity (relative survival below 20%) was observed up to the highest applied test substance concentration. The test substance did not cause any biologically relevant increase in the mutant frequencies both without S9 mix and after the addition of a metabolizing system in all experiments performed independently of each other. Thus, the test substance 1,5-Pentanediol is not mutagenic in the HPRT locus assay under in vitro conditions in CHO cells in the absence and the presence of metabolic activation.
According to the results an in vitro micronucleus assay, the test substance 1,5-Pentanediol did not lead to a increase in the number of micronucleated cells either without S9 mix or after the addition of a metabolizing system in two experiments performed independently of each other. The frequencies of micronuclei after test substance treatment were within the range of the concurrent negative control values at both exposure times and within the range of the 95% control limit of our historical negative control data. The increase in the frequencies of micronuclei induced by the positive control substances MMC, Colchicine and CPA clearly demonstrated the sensitivity of the test system and/or the metabolic activity of the S9 mix employed. The values were compatible the range of the historical positive control data and, thus, fulfilled the acceptance criteria of this study.
Justification for classification or non-classification
Due to the negative results in several studies performed according to OECD guideline, no classification is required with respect to genetic toxicity according to Regulation 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
