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EC number: 600-261-6 | CAS number: 101990-44-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according OEDC/EU guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- (2-aminoethyl)[(6-chloropyridin-3-yl)methyl]amine
- EC Number:
- 600-261-6
- Cas Number:
- 101990-44-7
- Molecular formula:
- C8H12ClN3
- IUPAC Name:
- (2-aminoethyl)[(6-chloropyridin-3-yl)methyl]amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344/DuCrj
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 20 mg/kg bw/day (nominal)
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
Twenty-eight-day repeated dose toxicity test and fourteen-day recovery test in each dose group of 6 male and 6 female Fischer
strain ( F344 : DuCrj; 6 weeks old ) rats were conducted with test substance, NTN43412.
Four test groups consist of 3 dose groups at the highest dose level of 500mg/kg, lOOmg/kg and 20mg/kg and one control group,
and the recovery groups of the control group and 500mg/kg group.
The test results are summarized hereinafter.
1. No death due to toxicity of the test substance was observed throughout the study period. In the males and females in
500mg/kg group, acute poisoning symptoms such as salivation and lacrimation were occasionally found.
2. The body weight and body weight gain of the male and female 500mg/kg group were decreased, being accompanied by the
reduced food consumption during the administration period. But, they showed relatively a rapid recovery after the
administration period.
3. In the urinary examination at the end of administration period, the increase of urine volume, urinary pH and higher incidence
with protein positive cases were observed in the males and females in 500mg/kg group. And, urine volume was increased
even in females in lOOmg/kg group. But, these findings disappeared at the end of recovery period.
4. The hematological and blood chemical examinations showed no special findings.
5. The autopsy performed at the end of the administration period revealed the change of lobular pattern in the liver surface
and immature seminal vesicle gland with high incidence in the males in 500mg/kg group. The same findings were observed each
in one rat even at the dose level of lOOmg/kg dose group. But, these findings almost disappeared in the autopsy performed
at the end of the recovery period.
6. In the organ weight, increased kidney relative weight was observed in the males and females in 500mg/kg group at
the end of administration period. A slight increase of kidney relative weight was found in the females even at the end of
the recovery period. No special changes were seen in any other organ weights.
7. In the histopathological examination performed at the end of administration period, centrilobular hepatocyte swelling
was found with high incidence in the males and females in receiving 500mg/kg group. This finding disappeared at the
end of recovery period. No changes due to the test substance were seen in any other organs and tissues.
From the above mentioned results, no effect level ( NOEL ) in this study was estimated at 20mg/kg in the male and female rats.
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