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Diss Factsheets
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EC number: 208-655-6 | CAS number: 537-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In a reverse gene mutation assay in bacteria (Wollny HE, 2006) classified at validity 1 according to Klimisch scoring system, strains TA1535, 1537, 98, 100 and 102 of S. typhimurium were exposed to cerium carbonate, (65.62 % a. i.), at concentrations of 3 to 5000 µg/plate in the presence and absence of mammalian metabolic activation. Cerium carbonate was tested up to precipitating concentrations. The positive controls induced the appropriate responses in the corresponding strains. There was no evidence of induced mutant colonies over background in any strains in the absence and presence of metabolic activation. Therefore, dicerium tricarbonate is considered to be non-mutagenic in this Salmonella typhimurium reverse mutation assay.
In a mammalian cell cytogenetics assay (chromosome aberration assay) (Schulz, 2006) classified at validity 1 according to Klimisch scoring system, primary lymphocyte cultures were exposed to Cerium carbonate (65.62% of purity), in distilled water, at concentrations of 45.6 - 7020 µg/mL or 87.0 - 2500 µg/mL with and without metabolic activation. Cerium carbonate was tested up to precipitating concentrations. Positive controls induced the appropriate response. There was no evidence of chromosome aberration induced over background in the presence or the absence of metabolic activation. Therefore, dicerium tricarbonate is considered to be non-clastogenic in this chromosome aberration test when tested up to precipitating concentrations.
In a mammalian cell gene mutation assay (HPRT locus) (Wollny, 2006) classified at validity 1 according to Klimisch scoring system, Chinese hamster V79 cells cultured in vitro were exposed to Cerium carbonate, in deionised water, at concentrations of 143.8 to 2300 µg/mL in the presence and absence of mammalian metabolic activation. Cerium carbonate was tested up to insoluble concentrations. The positive controls induced the appropriate response. There was no evidence of induced mutant colonies over background in the presence or the absence of metabolic activation. Therefore, dicerium tricarbonate is considered to be non-mutagenic in this HPRT assay.
Short description of key information:
Reverse gene mutation assay in bacteria (Ames test): negative
Chromosomal aberration in vitro: negative
Mammalian cell gene mutation assay (HPRT locus) in vitro: negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on results of three genetic toxicity tests in vitro, the substance does not need to be classified according to GHS (Regulation (EU) 1272/2008) and also does not need to be classified according to DSD (67/548/EEC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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