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EC number: 500-094-8 | CAS number: 37208-53-0 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Assessment of the toxicokinetic behaviour as can be derived from the available information.
- Adequacy of study:
- weight of evidence
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
- Principles of method if other than guideline:
- Review of findings from reports summarised in the dataset.
Test material
Constituent 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Given the vapour pressure and water solubility of the commercial NLP polyol, it is likely that some absorption of the lower molecular weight material will occur in the lung. Absorption of propoxylated nitrilotriethanol is likely when administered orally. Nitrilotriethanol is absorbed, probably by passive diffusion rather than active transport. Propane-1,2-diol and [(methylethylene)bis(oxy)]dipropanol (and, presumably, oxydipropanol) are also absorbed, probably by passive diffusion, when administered orally. Thus it is probable that oligomers may be absorbed, probably by passive diffusion.
Nitrilotriethanol is also absorbed when administered dermally, thus it is possible that propoxylated nitrilotriethanol may also be absorbed by the
dermal route. - Details on distribution in tissues:
- Given the logP values, it is likely that any absorbed oligomers of propoxylated nitrilotriethanol will be widely distributed in body water and it is unlikely that they will accumulate in tissues.
- Details on excretion:
- In the event that higher molecular weight material is absorbed, it is likely to be excreted in bile. Lower molecular weight unmetabolised oligomer is likely to be excreted in urine. In rat the molecular weight threshold for biliary excretion is around 350, in human it is about 500. The material most likely to be absorbed is likely to be hydrolysed and the products appear in urine, except when the end point of metabolism is carbon dioxide. Carbon dioxide will be exhaled. If the hydrolysis is taken to completion, the nitrilotriethanol is likely to be excreted in urine, probably without further metabolism.
Metabolite characterisation studies
- Details on metabolites:
- Based on information from the propane-1,2-diol and trimer [(Methylethylene)bis(oxy)]dipropanol, if absorbed, the propane-1,2-diol moiety
of the propoxylated nitrilotriethanol could be further conjugated (with glucuronic acid or sulphate) or stepwise hydrolysed. Propane-1,2-diol is also
further metabolised, entering intermediary metabolism via lactic acid/pyruvic acid, and eventually being eliminated as carbon dioxide. If nitrilotriethanol is released, it is unlikely to be further metabolised.
Any other information on results incl. tables
There are no experimental studies on the toxicokinetics of propoxylated nitrilotriethanol. The toxicokinetics of propoxylated nitrilotriethanol is inferred from the core substance and propane-1,2-diol, oxydipropanol and [(methylethylene)bis(oxy)]dipropanol. Nitrilotriethanol has three hydroxy groups, thus NLP polyols are likely to consist predominantly of chains of between one and two propoxyl groups, with some chains containing three.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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