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Diss Factsheets
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EC number: 203-401-0 | CAS number: 106-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Evaluation de la toxicite d´agents d´activite´cosmetique cas du trichlorocarbanilide
- Author:
- Marty JP, and Wepierre J
- Year:
- 1 979
- Bibliographic source:
- Labo Pharma Problemes et techniques, 286, April 1979
- Reference Type:
- review article or handbook
- Title:
- BUA-Stoffbericht No 153: p-chloraniline
- Author:
- BUA (Beratergremium umweltrelevanter Altstoffe) (BUA)
- Year:
- 1 995
- Bibliographic source:
- Gesellschaft Deutscher Chemiker (Hrsg Behret) VCH (Verlag Chemie), Weinheim
Materials and methods
- Principles of method if other than guideline:
- The LD50 of p-chloroaniline was determined through oral administration (gavage)
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report): p-chloroaniline
- Analytical purity: no data
- Radiochemical purity (if radiolabelling): between 98 and 99%
- Specific activity (if radiolabelling): 19.7 mCi/mmol
- Locations of the label (if radiolabelling): parachloroaniline-14C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Cesal , France
- Weight at study initiation: 170 g
- Fasting period before study: no
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C ± 1 °C
- Humidity (%): 50 ± 10%
- Air changes (per hr): 10 times per hour
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1%
- Amount of vehicle (if gavage): 10 mL/kg - Doses:
- not reported
- No. of animals per sex per dose:
- Not reported
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs - Statistics:
- LD50 was calculated according to the method of Litchfield and Wilcoxon, J. Pharmacol. Exp. Ther 96, 99, 1945
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 340 mg/kg bw
- 95% CL:
- 280 - 414
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 300 mg/kg bw
- 95% CL:
- 246 - 366
- Clinical signs:
- other: response to the touch, restlessness, tremors and respiratory difficulties, cyanosis and a more advanced stage of intoxication
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Like other chloroanilines, the primary toxic effect of 4-chloroaniline is methaemoglobin formation. Taking into account that humans are much more sensitive to methaemoglobin producing substances than rats and that sufficient results of studies with cats, better suited to judge the level of toxicity for humans, are not available, 4-chloroaniline is classified as Toxicity Category III.
- Executive summary:
Marty (1979):
The LD50 of p-chloroaniline was determined through oral administration (gavage).
LD 50 was estimated to be 340 mg/kg bw (280-414) and 300 mg/kg bw (246-366) according to the method of Lichfield and Wilcoxon.
Response to the touch, restlessness, tremors and respiratory difficulties, cyanosis and a more advanced stage of intoxication.
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