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EC number: 255-449-7 | CAS number: 41583-09-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
As the substance is a salt of phosphate, effects can be read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from the read across substance melamine CAS 108 -78 -1 is justified. All effect values are minimum values as the molar ratio anion: cation equals 1.74.
Short-term toxicity to fish
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. According to Pagga, 1979 (BASF SE) a 48h-LC50 > 500 mg/L was determined on Leuciscus idus. The substance is acutely not harmful to fish.
Long-term toxicity to fish
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. The studies of Adema, 1982 (DSM) and Goodrich, 1984 (American Cyanamid) with comparable reliability and adequacy were used in a weight of evidence approach. The NOEC for the egg/larvae stage was determined to be >1000 mg/L. Both results indicate a low subchronic toxicity to developmental fish.
Short-term toxicity to aquatic invertebrates
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. Based on the reported studies, which are consistent, an EC50 of 200 mg/L was determined in a study (Frazier, 1988 (American Cyanamid Co.)) performed with Daphnia magna. The substance is acutely not harmful to freshwater invertebrates.
Long-term toxicity to aquatic invertebrates
The chronic toxicity to aquatic invertebrates was assessed in a study (BASF SE, 2014) conducted with the target substance according to OECD 211 (2012). Daphnia magna was exposed to the test substance for 22 days. The NOEC based on reproduction was determined to be > 10 mg/L. The chronic toxicity and the reproduction toxicity of melamine to Daphnia magna is low.
Toxicity to algae and cyanobacteria
No data with the test substance were available. A weight of evidence approach with the read across substance melamine (CAS 108-78-1) is applied. Based on the reported studies, which are consistent, an EC50 of 325 mg/L and a NOEC of 98 mg/L were determined in a study performed with Pseudokirchneriella subcapitata (Drodowski, 1988 (American Cyanamid)).
Toxicity to microorganims
No data with the test substance were available. A weight of evidence approach with the read across substance melamine (CAS 108-78-1) is applied.
The study of Hockenbury 1977 is the relatively best reported one and was therefore selected as the lead study in the weight of evidence approach. After 2 hours the EC0 was determined to be > 100 mg/L. The toxicity of melamine to 3 different microorganisms is low.
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