Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-201-1 | CAS number: 3030-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (limited documentation, occlusive treatment, no data on substance purity)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (limited documentation, 1, 5, 15 min and 20 h exposure duration, occlusive treatment, no scoring at 72 h)
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(2-dimethylaminoethyl)(methyl)amine
- EC Number:
- 221-201-1
- EC Name:
- Bis(2-dimethylaminoethyl)(methyl)amine
- Cas Number:
- 3030-47-5
- Molecular formula:
- C9H23N3
- IUPAC Name:
- (2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl)dimethylamine
- Details on test material:
- - Name of test substance (as cited in study report): Pentamethyl-diaethylen-trieamin
- Analytical purity: no data
- Physical state: liquid
- Density: 0.829 g/cm³
- Substance number: XXIII/80
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Source: Gaukler
- Weight at study initiation: 2.94 kg (male), 3.78 kg (female)
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated site served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: area of application: 2.5 x 2.5 cm
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 1, 5, 15 min and 20 h
- Observation period:
- 8 days (reading intervals: upon removal of test patch, 24 h, 48 h, 5 d, 7 d, and 8 d after start of treatment)
- Number of animals:
- 2 (20 h exposure only in 1 animal)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Remarks:
- (5 min exposure)
- Time point:
- other: 24 h
- Remarks on result:
- other: non-reversible, leather-like, black necrosis
- Irritation parameter:
- other: necrosis
- Basis:
- animal #2
- Remarks:
- (5 min exposure)
- Time point:
- other: 24 h
- Remarks on result:
- other: non-reversible leather-like, red-brown necrosis
Any other information on results incl. tables
Skin irritation:
Exposure duration |
Readingpoint |
Animal 1 |
Animal 2 |
||||
Ery |
Ed |
Remarks |
Ery |
Ed |
Remarks |
||
1 min |
Day 0 |
2 |
0 |
Blotchy necrosis |
2 |
- |
blotchy |
24 h |
2 |
2 |
Necrosis, ecchymosis |
- |
- |
Blotchy necrosis |
|
48 h |
- |
- |
Blotchy necrosis |
- |
- |
Blotchy necrosis |
|
Day 5 |
- |
- |
Parchmenty necrosis |
- |
- |
Parchmenty necrosis |
|
Day 7 |
- |
- |
Scaling |
- |
- |
Scaling |
|
Day 8 |
- |
- |
Necrosis |
- |
- |
Scaling |
|
5 min |
Day 0 |
3 |
- |
Ecchymosis |
2 |
- |
Brownish |
24 h |
2 |
- |
Leather-like, black necrosis |
- |
- |
Leather-like, red-brown necrosis |
|
48 h |
- |
- |
Leather-like, hard necrosis |
- |
- |
Leather-like, red-brown necrosis |
|
Day 5 |
- |
- |
Hard, movable necrosis |
- |
- |
Leather-like, red-brown necrosis |
|
Day 7 |
- |
- |
Hard, movable necrosis |
- |
- |
Leather-like/hard red-brown necrosis |
|
Day 8 |
- |
- |
Hard, movable necrosis |
- |
- |
Leather-like/hard, red-brown necrosis |
|
15 min |
Day 0 |
3 |
- |
Ecchymosis, yellow |
2 |
- |
Brownish, overleaping necrotic centre |
24 h |
2 |
- |
Leather-like, black necrosis |
- |
- |
Hard, movable black necrosis |
|
48 h |
- |
- |
Leather-like, black necrosis |
- |
- |
Hard, movable black necrosis |
|
Day 5 |
- |
- |
Leather-like necrosis |
- |
- |
Hard, movable, black necrosis |
|
Day 7 |
- |
- |
Leather-like necrosis |
- |
- |
Hard, movable black necrosis |
|
Day 8 |
- |
- |
Leather-like necrosis |
- |
- |
Hard, movable black necrosis |
|
20 h |
24 h |
2 |
- |
Soft, black, anaemic necrosis |
|
|
|
48 h |
2 |
- |
Hard movable, black necrosis |
|
|
|
|
Day 5 |
- |
- |
Hard, movable necrosis |
|
|
|
|
Day 7 |
- |
- |
Hard, movable necrosis |
|
|
|
|
Day 8 |
- |
- |
Hard, movable necrosis |
|
|
Ery: Erythema
Ed: Edema
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.