Registration Dossier
Registration Dossier
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EC number: 270-299-2 | CAS number: 68424-38-4 This substance is identified by SDA Substance Name: C16-C18 alkyl carboxylic acid sodium salt and SDA Reporting Number: 19-006-04.
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- 068424-26-0
- Cas Number:
- 068424-26-0
- IUPAC Name:
- 068424-26-0
- Reference substance name:
- Fatty acids, C16-18 and C18-unsatd.
- EC Number:
- 266-932-7
- EC Name:
- Fatty acids, C16-18 and C18-unsatd.
- IUPAC Name:
- Fatty acids, C16-18 and C18-unsatd.
- Details on test material:
- no data
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
- Water solubility: soluble
Sampling and analysis
- Analytical monitoring:
- not specified
- Details on sampling:
- no data
Test solutions
- Vehicle:
- no
- Details on test solutions:
- First a stock solution of 10 g/l of the test substance was prepared. From this solution appropriate aliquots were pipetted into the test vessels and filled up to final volumes of 5 l with standard dilution water (pH 7.8 ± 0.2, about 250 mg CaCO3/ll, oxygen saturated)
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Mortality (prior to test): < 0.1%
Pretreatment: none
Feeding: not during the test
Number of test organisms: 10 fish per concentration
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- about 250 mg CaCO3/l
- Test temperature:
- 22.5 - 23.5°C
- pH:
- 8.0 - 8.1
- Dissolved oxygen:
- 8.6 - 9.8 mg O2/l
- Salinity:
- no data
- Nominal and measured concentrations:
- Concentration of the test substance: 16, 32, 45, 64 and 90 mg/l
- Details on test conditions:
- Test vessels: 10 l fish basins containing 5 l test water
Light: about 16 hours illumination per day
- Concentration of the test substance: 16, 32, 45, 64 and 90 mg/l
-Mortalities are recorded at 0, 6, 24, 48, 72 and 96 hours - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 27 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 77 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- the fish did not show any abnormal behaviour.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Mortality [%]
Conc.
Incubation time [h]
[mg product/l]
0
6
24
48
72
96
16
0
0
0
0
n.d.
0
32
0
0
0
0
n.d.
0
45
0
0
0
40
n.d.
60
64
0
0
0
60
n.d.
80
90
0
0
0
100
n.d.
100
n.d. = not determined
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Fatty acids, C16-18 and C18-unsatd., sodium salts turned out to be moderately toxic to Zebra-fish.
- Executive summary:
The acute toxicity of Fatty acids, C16-18 and C18-unsatd., sodium salts to Zebra-fish was determined according to the OECD-guideline 203.
The product was tested in a concentration range of 16 to 90 mg product/l (nominal).
The incubation period was 96 hours under semistatic conditions ( the test-solution were renewed daily).
Following results were obtained:
LC0: 32 mg product/l = 27 mg active matter/l
LC50: 54 mg product/l = 46 mg active matter/l
LC100: 90 mg product/l = 77 mg active matter/l
Fatty acids, C16-18 and C18-unsatd., sodium salts turned out to be moderately toxic to Zebra-fish.
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