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EC number: 231-891-6 | CAS number: 7775-19-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Regulations to the Federal Hazardous Substances Labelling Act.
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- Substance pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium metaborate tetrahydrate
- EC Number:
- 600-663-1
- Cas Number:
- 10555-76-7
- Molecular formula:
- NaBO2*4H2O
- IUPAC Name:
- Sodium metaborate tetrahydrate
- Details on test material:
- - Name of test material: 8 mol sodium metaborate
- Physical state: White crystalline solid with no niticeable odour.
- Analytical purity: Equivalent to 101 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dublin Laboratory Animals.
- Weight at study initiation: 210 to 258 g males
- Fasting period before study: 18 h
- Housing: Housed in groups in ire mesh cages suspended above te droppings.
- Diet: Ad libitum
- Water: Ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- No data
- Doses:
- Actual dose levels of 0.213, 0.459, 0.990, 2.13, 4.59 and 9.90 g/kg of bw.
On a corrected basis these doses are equivalent to 0.215, 1.0, 2.15, 4.64 and 10 g/kg respectively. - No. of animals per sex per dose:
- 5 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs - Statistics:
- Statistical analysis of the mortality data was by the moving average method.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2.33 other: g/kg
- Based on:
- test mat.
- 95% CL:
- 1.6 - 3.39
- Remarks on result:
- other: Corrected basis
- Mortality:
- Deaths occurred at 2.15, 4.64 and 10.0 g/kg dose groups.
- Clinical signs:
- other: see Remark
- Gross pathology:
- Gross autopsies performed on the rats which died showed congested lungs, kidneys and adrenals and severe irritation of the gastrointestinal tract. Additional findings noted consistently among the rats at the 10.0 mg/kg dosage level included small haemorrhagic areas present in the mucosal layer of the pyloric portion of the stomach and in the intestinal tract.
Gross autopsies performed on the surviving rats at termination showed all organs to be within normal limits. - Other findings:
- The average body weight gain for each group was within the normal range of values for rats of the sex, age and strain used in this study.
Any other information on results incl. tables
Mortality results during the 14-day observation period are presented below. Values are numbers of animals dead/number of animals tested, cumulative.
Dose (g/kg) |
Time of death |
|||||||||
Hours |
Days |
|||||||||
1 |
2 |
4 |
24 |
2 |
3 |
4 |
5 |
6 |
7 |
|
0.215 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0.464 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
1.00 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
2.15 |
0/5 |
0/5 |
0/5 |
2/5 |
2/5 |
2/5 |
2/5 |
2/5 |
2/5 |
2/5 |
4.64 |
0/5 |
2/5 |
2/5 |
5/5 |
|
|
|
|
|
|
10.0 |
0/5 |
2/5 |
4/5 |
5/5 |
|
|
|
|
|
|
Applicant's summary and conclusion
- Interpretation of results:
- other: EU GHS criteria not met
- Conclusions:
- The acute oral toxicity of 8 mol sodium metaborate was evaluated in male albino rats in accordance with the technique specified in the Regulations to the Federal Hazardous Substances Labelling Act. The acute oral LD50 was found to be 2.33 g/kg bw with 95 % confidence limits from 1.60 to 3.39 g/kg. On the basis of these result, 8 mol sodium metaborate was classed as toxic by ingestion.
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