Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 208-754-4 | CAS number: 540-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The key study for this endpoint is based on the well described literature study of Lanno and Dixon (1994) in which fathead minnows were exposed to potassium thiocyanate. The NOEC for decreased egg production, overt goitre, increased time to first spawn was 1.1 mg/L SCN-, equivalent to 1.84 mg/L KSCN
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.84 mg/L
Additional information
Four literature studies were available for this endpoint, two for KSCN, and one for SCN- (with the identity of the cation unknown). The study on the SCN- was considered unusable as only the abstract was available. The remaining studies described toxicity of potassium thiocyanate to fathead minnow (Pimephales promelas) and rainbow trout (Oncorhynchus mykiss) and toxicity of sodium thiocyanate to Cyprinus carpio. The key values from these studies were:
124 d NOEC = 1.1 mg/L SCN- (P. promelas) and 16 wk NOEC = 77 mg/L (O. mykiss). Both studies were well described and with analytical monitoring of the SCN- concentrations. The study describing chronic toxicity to P. promelas was chosen as the key study for this endpoint due to the lower NOEC value of 1.1 mg/L SCN- (1.84 mg/L KSCN)
As there were no GLP studies for this endpoint, further long term studies with fish were waived based on the short term data for daphnia, fish and algae; where it was shown that fish were the least sensitive organisms, thus it would not be expected that they would be more sensitive in a long term study, thus conducting a long term fish study would add no scientific value, except to use a lower assessment factor. Also due to ethical reasons, it would be inappropriate to conduct a long term fish study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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