Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 306-479-5 | CAS number: 97280-83-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 oral > 2000 mg/kg (BASF AG, 1989)
LC50 inhalation > 3.9 mg/L (inhalation risk test, BASF AG, 1989)
LD50 dermal > 2000 mg/kg (read across to other hogher olefins, SIDS documents 2004 and 2007 on the higher olefin category)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute oral toxicity:
The potential to induce acute toxicity following oral administration of the test substance was tested similar to OECD test guideline 401 (BASF AG, 1989). Five female and male rats treated by gavage with 2000 mg/kg isododecene using CMC as vehicle and analyzed for 14 days. All animals survived treatment and did not show any signs of clinical symptoms and pathological findings. Hence, the LD50 of isododecene is > 2000 mg/kg.
Acute inhalation toxicity:
The potential of the test substance to induce acute toxicity following inhalation was tested in three male and female rats in a non-GLP study similar to OECD test guideline 403 with the Inhalation Hazard test (BASF AG, 1989). Rats were exposed by head/nose-only exposure to a calculated vapor of 3.8 mg/L isododecene for 7 h. While none of the animals died following exposure or showed pathological findings, the following clinical symptoms were recorded during exposure: accelerated breathing during the entire time of exposure, eyelid closure and attempts to escape during the first minute of exposure. Once exposure has been finished, no further clinical symptoms were monitored.
Acute dermal toxicity:
A study with isododecene to analyze its acute dermal toxicity is not available. However, the potential to induce dermal toxicity has been analyzed in two structural analogues, (alkenes C11-C13, C12, CAS 68526-58-9 and 1-dodecene CAS 112-41-4) and are described in an OECD SIDS report (SIDS Initial Assessment Report for SIAM19, Higher olefins category, 2004) . While no mortality was observed in all rabbits treated up to 2446.0 mg/kg of alkenes C11 -C13, C12, one out of the four rabbits dies on the 7th day of observation following treatment with 1 -dodecene. Based on this weight of evidence approach, higher order olefins including isododecene are not expected to induce acute dermal toxicity (LD50 > 2000 mg/kg).
Justification for classification or non-classification
Isododecene does not warrant classification for acute toxicity according to Directive 67/548/EEC (DSD) and EC1272/2008 (CLP).
Isododecene belongs to the category of hydrocarbons and exhibits a kinemiatic viscosity below 20.5 mm2/s. Hence, the test substance is classified with Xn/R65 and Danger/H304 according to Directive 67/548/EEC (DSD) and EC1272/2008 (CLP), respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.