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EC number: 202-426-4 | CAS number: 95-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- A correlation study of biodegradability determinations with various chemicals in various tests
- Author:
- Gerike P, Fischer WK
- Year:
- 1 979
- Bibliographic source:
- Ecotoxicology and environmental safety 3, 159-173
Materials and methods
- Principles of method if other than guideline:
- 7 different tests for biodegradability (readily or inherent, respectively) were performed: 1) coupled units test (modification of the OECD confirmatory test to the use of the carbon analysis); 2) the Zahn-Wellens test; 3) the Japanese MITI test; 4) the Frensh AFNOR T 90-302 test; 5) the carbon dioxide evolution test according to Sturm; 6) the OECD screening test modified for the use of the carbon analysis; 7) the closed bottle test. Conclusions regarding the individual tests are drawn from comparisons with the other test results.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chloroaniline
- EC Number:
- 202-426-4
- EC Name:
- 2-chloroaniline
- Cas Number:
- 95-51-2
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 2-chloroaniline
- Details on test material:
- purity: not given in original reference
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: different (according to test guidelines of the 7 tests): from 1 drop of effluent/L to 2.5 g of sludge dry weight/L
- Duration of test (contact time):
- ca. 14 - ca. 42 d
Parameter followed for biodegradation estimationopen allclose all
- Parameter followed for biodegradation estimation:
- DOC removal
- Remarks:
- (for tests according to methods 1 to 6)
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Remarks:
- (for test according to method 5)
- Parameter followed for biodegradation estimation:
- other: COD (for tests according to methods 1 and 2)
- Parameter followed for biodegradation estimation:
- other: BOD (for tests according to methods 3 and 7)
Reference substance
- Reference substance:
- other: no reference substance, but 43 other compounds tested together with 2-chloroaniline (readily degrabable and non-degradable ones), which demonstrated the function of the test set-ups
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (DOC removal)
- Value:
- 94
- Sampling time:
- 10 d
- Remarks on result:
- other: test 2: Zahn-Wellens test
- Parameter:
- % degradation (DOC removal)
- Value:
- 21
- Sampling time:
- 14 d
- Remarks on result:
- other: test 3: MITI test
- Parameter:
- other: BOD14
- Value:
- 0
- Sampling time:
- 14 d
- Remarks on result:
- other: test 3: MITI test
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Remarks on result:
- other: test 5: Sturm test
- Details on results:
- further test results:
9% Degradation; DOC removal; 28 d; test 5: Sturm test
-7% Degradation; DOC removal; 19 d; test 6: OECD Screening test (conventional, i.e. no preaccl.)
-0% Degradation; BOD30; 30 d; test 7: Closed bottle test (conventional, i.e. not modified)
- 5-6% Degradation (DOC removal); couled united test (various sampling times)
Any other information on results incl. tables
no further data
Applicant's summary and conclusion
- Interpretation of results:
- inherently biodegradable
- Executive summary:
Gerike and Fischer (1979).
The authors investigated the comparability of several national and international test guidelines for the degradability of chemical compounds by wastewater microorganisms under aerobic conditions. The results of the most of these test strategies enabled to assess the ready biodegradability of the tested compounds.
It could be shown that 2-chloroaniline was degraded not or only to a minor degree in all tests for ready biodegradability. Thus, the conclusive outcome of the work of Gerike and Fischer is that the compound 2-chloroaniline is not readily biodegrabable.
Nevertheless, 2-chloroaniline appeared degradable only in the Zahn-Wellens test (94% after 10 d). Thus, as the Zahn-Wellens test is a study design for investigating the inherent biodegradability, it might be stated furthermore, that 2-chloroaniline is inherently biodegradable.
This overall conclusion that can be drawn from the couple of tests presented by Gerike and Fischer is fully in line with the conclusion drawn in BUA report 57 (see "5.2.1, rel other, BUA report 57, 1991 (part1/3)"). In the latter document the results of several publications to the degradability of 2-chloroaniline are presented and discussed.
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