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Diss Factsheets
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EC number: 233-060-3 | CAS number: 10026-13-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published, public domain information
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative Toxicity of Chloride Compounds of Phosphorus (POCl3, PCl3, PCl5) in single and repeated exposures
- Author:
- Molodkina NN
- Year:
- 1 973
- Bibliographic source:
- Toksikologiya Novykh Prom, Khim, Veshch. 13: 107-114
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- No further details.
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorus pentachloride
- EC Number:
- 233-060-3
- EC Name:
- Phosphorus pentachloride
- Cas Number:
- 10026-13-8
- Molecular formula:
- PCl5
- IUPAC Name:
- pentachloro-λ⁵-phosphane
- Details on test material:
- No further details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Mice are housed in a chamber of 100 liter capacity. Crystals of the test substance was administered to determine the lethal concentration of the test substance.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Mice are housed in a chamber of 100 liter capacity. Crystals of the test substance was administered to determine the lethal concentration of the test substance.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- colorimetry was used to determine the concentration of the test substance in the chamber.
- Remarks on duration:
- length of exposure not specified
- Concentrations:
- A range of concentrations were used to determine the lethal dose of phosphorus pentachloride.
- No. of animals per sex per dose:
- Not stated
- Details on study design:
- Crystals were introduced into a chamber of 100 liter capacity. The concentration of the test substance was determined by colorimetry.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.205 mg/L air (analytical)
- 95% CL:
- ca. 0.152 - ca. 0.283
- Remarks on result:
- other: Exposure duration unknown
- Mortality:
- Not stated
- Clinical signs:
- other: On administering lethal concentrations of phosphorus pentachloride, unrest was observed at the outset; the animals struck their face with their paws and were excited. In 5-15 minutes, a depression of the animals sets in, there was lack of coordination of
- Body weight:
- In the course of several days after the administration, the surviving animals became sluggish, they refused their feed and lost weight.
- Gross pathology:
- Not stated.
- Other findings:
- No further findings.
Any other information on results incl. tables
The LC50 for phosphorus pentachloride was determined to be 0.205 mg/l.
Applicant's summary and conclusion
- Interpretation of results:
- other: acute toxicity cat.2
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 for phosphorus pentachloride in the rat was calculated to be 0.205 mg/l.
- Executive summary:
The LC50 for phosphorus pentachloride in the rat was calculated to be 0.205 mg/l under the conditions of this study (unknown duration of exposure). Clinical signs observed after administration of the test substance included unrest, lack of coordination, fibrillar twitching, sweating, sharply reduced and laboured breathing. The substance is classified acute toxicity cat.2 according to the CLP regulation (EC N.1272/2008)
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