Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-760-2 | CAS number: 38051-10-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
Description of key information
NOEC = 17 mg/kg dry weight
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for terrestrial plants:
- 17 mg/kg soil dw
Additional information
No toxicity data on terrestrial plants are available for 2,2-bis(chloromethyl)trimethylene bis(bis(2-chloroethyl)phosphate).
Long-term effects on higher plants were measured for tris(2-chloro-1-methylethyl) phosphate (TCPP) in 2003.
Read-across
Read-across of the long-term effects data on higher plants from TCPP could be considered on the following grounds:
- TCPP and 2,2-bis(chloromethyl)trimethylene bis(bis(2-chloroethyl)phosphate) have similar soil adsorption properties (see also section 5.4.1 Adsorption/desorption) indicating that the bioavailability of the substances to soil organisms could be comparable. In particular the closeness in value of log Kow and log Koc values between the substances suggests that they would be expected to partition in the terrestrial environment in a very similar way.
- Test results suggest a consistent pattern of toxicity for TCPP and 2,2-bis(chloromethyl)trimethylene bis(bis(2-chloroethyl)phosphate). This is indicative of a consistent mode of action in higher plants, and the similarities in chemical structure between the substances would support this.
- Reliable chronic toxicity data for aquatic plants (freshwater algae) indicate that the NOEC for 2,2-bis(chloromethyl)trimethylene bis(bis(2-chloroethyl)phosphate) lies within a factor of only 4 of the EC10 value for TCPP (NOEC = 10 mg/L, resp. EC10 = 42 mg/L. not further reported here).
Long-term toxicity
The study reported the results of emergence and growth tests with the plant species Triticum aestivum (Wheat), Sinapis alba (Mustard) , Lactuca sativa (Lettuce) exposed to TCPP. The tests fulfilled the criteria for acceptability for determining a PNEC. The lowest NOEC determined in the tests was 17 mg/kg dry weight for emergence of L.sativa seedlings. The lowest NOECs determined for S. alba and L. sativa were 28 and 18 mg/kg respectively based on 21-day post emergence plant wet weight.
References:
- European Union Risk Assessment Report "2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate]" (V6), CAS 38051-10-4, May 2008
- European Union Risk Assessment Report“Tris(2-chloro-1-methylethyl) phosphate” (TCPP), CAS 13674-84-5, May 2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)