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EC number: 236-921-1 | CAS number: 13548-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
No hematological, hepatic, or renal effects or changes in body weight were observed in study in Sprague-Dawley rats exposed to 3.6 chromium(III)/kg/day as chromium chloride in drinking water for 1 year. The No-observed-adverse-effect level (NOAEL) for systemic effect of chromium chloride is considered to be 3.6 mg Cr(III)/kg/day as chromium chloride.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Link to relevant study records
- Endpoint:
- carcinogenicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: summarized in a well-known publication
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Sprague-Dawley rats were exposed to 3.6 mg chromium(III)/kg/day as chromium trichloride in drinking water for 1 years.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Route of administration:
- oral: drinking water
- Vehicle:
- not specified
- Details on exposure:
- Sprague-Dawley rats were exposed to 3.6 mg chromium(III)/kg/day as chromium trichloride in drinking water for 1 years.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 1 year
- Frequency of treatment:
- once daily
- Post exposure period:
- n/a
- Remarks:
- Doses / Concentrations:
25 ppm chromium chloride/kg/day (equal to 3.6 mg chromium(III)/kg/day)
Basis:
nominal in water - No. of animals per sex per dose:
- N/A
- Control animals:
- not specified
- Observations and examinations performed and frequency:
- N/A
- Sacrifice and pathology:
- N/A
- Details on results:
- It was noted no change in body weight, macroscopic or microscopic pathology, or clinical chemistry variables.
- Relevance of carcinogenic effects / potential:
- No hematological, hepatic, or renal effects or changes in body weight were observed in study in Sprague-Dawley rats exposed to 3.6 chromium(III)/kg/day as chromium chloride in drinking water for 1 year.
- Dose descriptor:
- NOAEL
- Effect level:
- 3.6 mg/kg bw/day (nominal)
- Based on:
- element
- Remarks:
- chromium(III)
- Sex:
- male/female
- Basis for effect level:
- other: It was noted no change in body weight, macroscopic or microscopic pathology, or clinical chemistry variables at a concentration of 3.6 mg Cr(III)/kg/day.
- Remarks on result:
- other: Effect type: toxicity (migrated information)
- Conclusions:
- No-observed-adverse-effect level (NOAEL) for systemic effect of chromium chloride is considered to be 3.6 mg Cr(III)/kg/day as chromium chloride.
- Executive summary:
The report was evaluated against data from a drinking water study in which rats were exposed to drinking water concentrations of Cr(III)Cl3 at a concentration of 3.6 mg chromium(III)/kg bw/day as chromium chloride for a period of 1 year, which did not result in significant alterations in body weight gain. Chronic oral exposure to chromium(III) compounds did not result in any target organ toxicity in animals. It was noted no change in body weight, macroscopic or microscopic pathology, or clinical chemistry variables. The study suggested a no-observed-adversed-effect level (NOAEL ) at 3.6 mg trivalent chromium/kg bw/day.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 16.5 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Justification for classification or non-classification
Based on one read-across study, no indication is given for carcinogenicity of chromium(III) compounds such as chromium trinitrate and thus the substance is not classified for carcinogenicity according to CLP (Regulation EC No 1272/2008) or DSD (Directive 67/548/EEC).
Additional information
The report was evaluated against data from a drinking water study in which rats were exposed to drinking water concentrations of CrCl3 at a concentration of 3.6 mg chromium(III)/kg bw/day as chromium chloride for a period of 1 year, which did not result in significant alterations in body weight gain. Chronic oral exposure to chromium(III) compounds did not result in any target organ toxicity in animals. It was noted no change in body weight, macroscopic or microscopic pathology, or clinical chemistry variables. The study suggested a no-observed-adverse-effect level (NOAEL ) at 3.6 mg trivalent chromium/kg bw/day, equivalent to 16.5 mg chromium trinitrate/kg bw/d.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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