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Diss Factsheets
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EC number: 210-871-0 | CAS number: 624-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2006-02-22 to 2006-04-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The objective of this study (WIL-160126) was to determine the critical period of exposure during lactation required to replicate lower pup body weight results at 5, 20 and 80 ppm in a concurrent two-generation reproductive toxicity study in rats (WIL-160122; Nemec, 2006). Although the lower mean body weights and body weight gains noted in the two-generation reproductive toxicity study were occasionally statistically significantly different from the control group, the effects did not occur in an exposurerelated manner. Therefore, the current study (WIL-160126) was conducted to determine if the lower pup body weight effects noted in the two-generation study could be reproduced under conditions of exposure of the F0 adults during discrete periods of F1 postnatal development. As a result, the maternal animals in the current study (WIL-160126) were exposed to the test article at exposure levels of 5, 20 and 80 ppm during 1 of 3 selected exposure periods (lactation days 5-12 [Subset I], 13-20 [Subset II] or 5-20 [Subset III]).
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- Dimethyl disulphide
- EC Number:
- 210-871-0
- EC Name:
- Dimethyl disulphide
- Cas Number:
- 624-92-0
- Molecular formula:
- C2H6S2
- IUPAC Name:
- (methyldisulfanyl)methane
- Details on test material:
- Source: Odor Tech, Pineville, Louisiana on behalf of Arkema Inc.
Batch no. 05.05.05
Purity: 99.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure (if applicable):
- whole body
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
Results and discussion
Any other information on results incl. tables
All dams in all 3 subsets survived to the scheduled necropsies on lactation day 21. There were no exposure-related clinical or macroscopic findings noted for the maternal animals at any exposure level in Subsets I, II and III. Lower mean maternal body weight gains with reduced food consumption were observed in the 80 ppm group in Subsets I, II and III during the first week of exposure when compared to the control group. At 20 ppm, lower mean maternal body weight gain and reduced food consumption were noted only on lactation days 5-7 in Subset III; however, the body weight effect at this exposure level was not observed in Subset I or Subset II. Mean maternal body weights, body weight gains and food consumption in the 5 ppm group were unaffected by test article exposure. There were no effects on the number of pups found dead, and there were no clinical or macroscopic findings noted for the F1 pups as a result of maternal exposure at any concentration in Subsets I, II and III. There were no effects on pup body weights when maternal animals were exposed to 5, 20 or 80 ppm dimethyl disulfide during lactation days 5-12 (Subset I), lactation days 13-20 (Subset II) or lactation days 5-20 (Subset III).
Applicant's summary and conclusion
- Conclusions:
- This study (WIL-160126) was conducted in order to determine if the pup body weight effects noted in the concurrent two-generation study (WIL-160122; Nemec, 2006) at exposure levels of 5, 20 and 80 ppm were a true reflection of toxicity, and was designed to examine whether more abbreviated exposure regimens targeted during lactation or more sustained exposure was necessary to replicate the effect on pup body weights. Based on the results of this study, no effects were noted on pup body weights when dams were exposed to dimethyl disulfide at concentrations of 5, 20 and 80 ppm for 1 week during lactation days 5-12 (Subset I) or lactation days 13-20 (Subset II), or for 2 weeks during lactation days 5-20 (Subset III). Therefore, the body weight effects noted for the F1 pups in the concurrent two-generation study (WIL-160122) at 5, 20 and 80 ppm were not replicated in the current study (WIL-160126) when abbreviated exposure regimens were targeted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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