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EC number: 201-289-8 | CAS number: 80-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (no GLP).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (no GLP)
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method which in principle was comparable to the OECD guideline 401. A test group consisting of 5 animals/dose was treated by single gavage with an aqueous solution of the test substance. Animals weight was taken prior to application, at regular intervals during the observation period and one day before termination. The animals were observed for mortality and for clinical signs of toxicity for a period of 14 days. Animals that died during the observations period were subjected to necropsy. At the end of the observation period, the surviving animals were sacrificed for the purpose of necropsy. The LD50 value was estimated on the basis of the observed mortalities
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(4-tert-butylbenzyl)propionaldehyde
- EC Number:
- 201-289-8
- EC Name:
- 2-(4-tert-butylbenzyl)propionaldehyde
- Cas Number:
- 80-54-6
- Molecular formula:
- C14H20O
- IUPAC Name:
- 3-(4-tert-butylphenyl)-2-methylpropanal
- Details on test material:
- - Name as cited in document: Lilial
- Analytical purity: 99%
- Batch No.: not reported
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague Dawley- Hagemann
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age at study initiation: not reported
- Body weight at study initiation: Range (male); 210-290 g, range (female); 170 - 220 g
- Fasting period before study: 15-20 h before application
- Diet: Herian MRH- Haltung; H. Eggermann KG
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6.8%; 10%; 14.7%; 21.5%; 31.6% in 0.5% CMC
- Amount of vehicle: 10 ml/kg bw
- Concentration of vehicle: 0.5 %
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
- Doses:
- 681; 1000; 1470; 2150; 3160 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior to application (day 1), on day 4 or 5, day 8 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross necropsy - Statistics:
- Test for homogeniety: chi squared test
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 390 mg/kg bw
- 95% CL:
- 1 019 - 1 867
- Remarks on result:
- other: LD50 was determined by probit analysis (Slope factor 1.94). Finney, D. J., Probit analysis, Cambridge University Press, 3rd Edition., 1971.
- Mortality:
- see table 1 in " Remarks on results..."
- Clinical signs:
- other: see table 2 in " Remarks on results...".
- Gross pathology:
- No abnormality was seen in survivors at the end of the study period.
Animals found dead:
- Heart: acute dilation, acute hyperemia
- Liver: clay yellow, grey-whitish, colouring of the periphery of the lopes
Any other information on results incl. tables
Table 1: Progression of mortality within the observation period
Dose (mg/kg bw) |
No. of animals |
Mortality within |
||||
1h |
1 d |
2 d |
7 d |
14 d |
||
681 |
5M |
0/5 |
0/5 |
0/5 |
1/5 |
1/5 |
5F |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
|
1000 |
5M |
0/5 |
1/5 |
1/5 |
1/5 |
1/5 |
5F |
0/5 |
4/5 |
4/5 |
4/5 |
4/5 |
|
1470 |
5M |
0/5 |
2/5 |
2/5 |
2/5 |
2/5 |
5F |
0/5 |
2/5 |
2/5 |
2/5 |
2/5 |
|
2150 |
5M |
0/5 |
2/5 |
2/5 |
2/5 |
3/5 |
5F |
0/5 |
2/5 |
3/5 |
3/5 |
3/5 |
|
3160 |
5M |
0/5 |
1/5 |
3/5 |
5/5 |
5/5 |
5F |
0/5 |
2/5 |
3/5 |
5/5 |
5/5 |
Table 2: Summary of the clinical signs that were recorded
681 mg/kg |
1000 mg/kg |
1470 mg/kg |
2150 mg/kg |
3160 mg/kg |
|
Dyspnea |
xxx |
xxx |
xxx |
xxx |
xxx |
Apathy |
xxx |
xxx |
xxx |
xxx |
xxx |
Abnormal position |
xxx |
xxx |
xxx |
xxx |
xxx |
Drunken gait |
xxx |
xxx |
xxx |
xxx |
xxx |
Atony |
xxx |
xxx |
xxx |
||
Loss of pain reflex |
xxx |
||||
Loss of corneal reflex |
xxx |
||||
Narcosis resembling state |
xxx |
||||
Tremor |
xxx |
||||
Spastic gait |
xxx |
xxx |
xxx |
xxx |
xxx |
Biting fit |
xxx |
||||
Rough fur coat |
xxx |
xxx |
xxx |
xxx |
xxx |
Diarrhea |
xxx |
||||
Skin erythema |
xxx |
xxx |
xxx |
||
Dehydration |
xxx |
xxx |
xxx |
||
Salivation |
xxx |
||||
Poor general condition |
xxx |
xxx |
xxx |
xxx |
xxx |
xxx symptoms observed
Table 3: Mean body weights after 14 days
Male |
Female |
|
Dose (mg/kg bw/d) |
Mean body weight after 13 days |
Mean body weight after 13 days |
681 |
270 (n=4) |
241(n=5) |
1000 |
278 (n=4) |
232 (n=1) |
1470 |
268 (n=3) |
194 (n=3) |
2150 |
260 (n=2) |
203 (n=2) |
3160 |
- |
- |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.