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EC number: 204-706-1 | CAS number: 124-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Undiluted methanesulfonyl chloride and a 10% w/v dilution in PEG 400 were applied for 24 hours under an occlusive patch to the to the fur-clipped skin of rabbits. Then, the animals were observed for seven days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methanesulphonyl chloride
- EC Number:
- 204-706-1
- EC Name:
- Methanesulphonyl chloride
- Cas Number:
- 124-63-0
- Molecular formula:
- CH3ClO2S
- IUPAC Name:
- methanesulfonyl chloride
- Details on test material:
- Test article name : Methane sulfonyl chloride
Cas n°: 124-63-0
Origin: Pennwalt Corporation
Batch no. : no data
Purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Species: Rabbit
- Strain: albino
- Source: no data
- Age: no data
- Weight at dosing: no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Housing: no data
- Diet: no data
- Water: no data
- Temperature: no data
-Humidity: no data
-Air changes: no data
- Photoperiod: no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- Three albino rabbits were treated dermally with a single dose of 2000 mg/kg and 6 additional rabbits were treated with a single dose of 200 mg/kg (2.0 ml/kg of a 10% w/v dilution in PEG 400). Individual dose were applied to the fur-clipped skin of the trunk under a pre-fitted impervious sleeve on each animal.
- Duration of exposure:
- 24 hours
- Doses:
- 200 (10% in PEG 400), 2000 (undiluted) mg/kg
- No. of animals per sex per dose:
- 3 or 6
- Control animals:
- no
- Details on study design:
- After a skin-contact period of 24 hours, the sleeves were removed and surviving animals were observed for seven days. No additional data available.
- Statistics:
- not apprpriate
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 200 - 2 000 mg/kg bw
- Mortality:
- - 2000 mg/kg (undiluted) : Mortality 3/3.
- 200 mg/kg (10% dilution) : No mortality. - Clinical signs:
- other: - 2000 mg/kg (undiluted) : initial skin contact evoked an intense pain reaction. One of the 3 rabbits died 30 min after exposure and the other 2 rabbits died during the following night. In each case the skin of the entire trunk was necrotic gray in app
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Conclusions:
- The acute dermal LD50 of Methanesulfonyl chloride was estimated to be greater than 200 mg/kg and lower than 2000 mg/kg in the rabbit.
- Executive summary:
Three albino rabbits were treated dermally with a single dose of 2000 mg/kg of methanesulfonyl chloride (purity unknown) and 6 additional rabbits were treated with a single dose of 200 mg/kg (2.0 ml/kg of a 10% w/v dilution in PEG 400). Individual dose were applied to the fur-clipped skin of the trunk under a pre-fitted impervious sleeve on each animal. After a skin-contact period of 24 hours, the sleeves were removed and surviving animals were observed for seven days.
No mortality was observed at 200 mg/kg and all of the animals remained asymptomatic and gained body weight during the observation period. When exposures were terminated, a well-defined erythema (score 2) was present over the entire trunk of each rabbit
All rabbits died at 2000 mg/kg. Initial skin contact evoked an intense pain reaction. One of the 3 rabbits died 30 min after exposure and the other 2 rabbits died during the following night. In each case the skin of the entire trunk was necrotic gray in appearance and the eyes were irritated.
The acute dermal LD50 of Methanesulfonyl chloride was estimated to be greater than 200 mg/kg and lower than 2000 mg/kg in the rabbit.
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