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EC number: 221-499-3 | CAS number: 3121-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48h) = 6.7 mg/L (nominal, confirmed with analytical data) (Daphnia magna, OECD 202)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.7 mg/L
Additional information
For the short-term toxicity to aquatic invertebrates one study with 2-methoxyethyl acrylate and one study with the analogue substance ethyl acrylate (CAS 140-88-5) are available.
In the key study, the toxicity of 2-methoxyethyl acrylate (CAS 3121-61-7) to Daphnia magna was investigated according to OECD guideline 202 and GLP under static conditions (Harris, 2012). Analytical determination of the test substance concentrations (1.0, 1.8, 3.2, 5.6 and 10 mg/L) showed measured test concentrations in a range of 102 - 111% of nominal values. As a result, an EC50 (48h) of 6.7 mg/L (nominal) was determined and a NOEC of 3.2 mg/L (nominal) was reported.
In addition, a supporting study investigating the structurally analogue substance ethyl acrylate (CAS 140-88-5) is reported (Staples et al., 2000). This study was carried out according to US EPA guideline OTS 797.1300 and GLP under flow-through conditions with Daphnia magna as test organism. Nominal test concentrations of 0.90, 1.8, 3.8, 7.5 and 15 mg/L were applied, with corresponding measured concentrations of 0.75, 1.7, 3.4, 6.3 and 12 mg/L. As a result, an EC50 (48h) of 7.9 mg/L (measured, arithm. mean) was determined.
In accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 read-across to another structurally related analogue substance was conducted. Read-across data from ethyl acrylate (CAS 140 -88 -5) were used, which was considered suitable for read-across.
Due to structural and property similarities with the tested analogue substance, it can be concluded that the above result also applies to 2-methoxyethyl acrylate (CAS 3121-61-7). For details see analogue justification in the overall summary of Chap 6.1 and in Chapter 13 of the Technical Dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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