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Diss Factsheets
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EC number: 600-736-8 | CAS number: 106276-80-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Only short summary available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test to study local effects of the test substance on rat skin
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
- EC Number:
- 226-999-5
- EC Name:
- 3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
- Cas Number:
- 5590-18-1
- Molecular formula:
- C22H6Cl8N4O2
- IUPAC Name:
- 3,3'-(1,4-phenylenediimino)bis(4,5,6,7-tetrachloro-1H-isoindol-1-one)
- Reference substance name:
- mono/bis-methoxy derivatives
- Molecular formula:
- C22-24H6-12Cl6-8N4O2-4
- IUPAC Name:
- mono/bis-methoxy derivatives
- Test material form:
- solid: bulk
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): GP 43692/I
- Physical state: no data
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 126 - 143 g, mean 134 g
- no further data
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- other: aqueous suspension with Gummi arabicum
- Details on exposure:
- TEST SITE
- Area of exposure: back, ca. 20 cm2
- Type of wrap if used: open conditions; animals were restrained in small cages during the exposure treatments
- Time intervals for shavings or clipplings: once before the start of the treatment
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 3 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.4cm^3/animal (= ca. 3 cm^3/kg bw)
- Concentration (if solution): 5%
- Constant volume or concentration used: no data
USE OF RESTRAINERS FOR PREVENTING INGESTION: yes - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 4 weeks; for 3 hours per day
- Frequency of treatment:
- daily 5 days/week
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.4 other: cm^3/animal
- Remarks:
- 5 % aqueous solution with gummi arabicum
- Dose / conc.:
- 150 mg/kg bw/day
- Remarks:
- Basis: nominal per unit body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Examinations
- Observations and examinations performed and frequency:
- Effects on skin were recorded 24 hrs after the previous treatment i.e. just before the next treatment; weighing was performed before and at the end of the study; no further information given, however, it can be deduced from the summary of results that resorption effects were also studied.
- Sacrifice and pathology:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Dermal irritation:
- no effects observed
- Description (incidence and severity):
- Local effects: no effects observed
Resorptive effects: no effects observed (no further data) - Mortality:
- not specified
- Body weight and weight changes:
- effects observed, non-treatment-related
- Description (incidence and severity):
- Mean body weight increased from 134 g on day 0 to 221 g on day 28 (176 - 286 g)
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Endocrine findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Remarks:
- local effects
- Effect level:
- ca. 150 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Highest dose test without local effects
- Dose descriptor:
- NOAEL
- Remarks:
- systemic effects
- Effect level:
- ca. 150 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: only body weight gain was determined; result: normal body weight gain; no details about study observation program
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.