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Diss Factsheets
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EC number: 485-230-3 | CAS number: 1455-42-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The toxicokinetics of the test substance were assessed by expert judgement.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
SPG (spiroglycol; 3,9-bis[1,1-dimethyl-2-hydroxyethyl]-2,4,8,10-tetraoxo-spiro [5,5] undecane; CAS no 1455-42-1) has a molecular weight of 304 Daltons. It is a white solid at room temperature, melting point 200oC. The substance is of very low vapour pressure (2.1 x 10-8Pa at 25oC), is of limited solubility in water (168 mg/L) and has a log Pow of 1.63 at 30oC. It is stable at pH 4, 7 or 9. The particle size distribution indicates that 91% are < 100 μm, 13.8 % < 10.2 μm and 5.4% <5.4 μm.
The substance is not classified as acutely toxic to rats, either when given orally or when given by inhalation. The substance is not classifiable in terms of skin and eye irritancy and skin sensitisation potential. The substance was negative in a bacterial point mutation assay and an assay for chromosomal aberrations. In the 28 day repeated dose study, rats received oral doses of 0, 15, 150 or 1000 mg/kg bw/d by gavage. There were no relevant toxicity findings. The no observed adverse effect level was stated as 1000 mg/kg bw/d.
Absorption
As the amount of substance of respirable size is relatively low, few particles will reach the lung alveolus. Given the low vapour pressure of the substance, it is unlikely that vapour will be inhaled in significant quantities.
The substance has some water solubility and has a log P 1.63, thus it is likely to be absorbed orally and through the skin. However, the substance appears to be non-toxic, thus thein vivostudies do not confirm that absorption has taken place.
Distribution
The log P indicates that the substance is likely to distribute in body water and not to bioaccumulate.
Metabolism
As the substance is a glycol, it is likely to be converted to the acid and/or conjugated with glucuronic acid or sulphate.
Excretion
Some conjugates are likely to be of sufficiently high molecular weight to suggest that they may be excreted in the bile of rat. Otherwise, the substance and metabolites are likely to be excreted in urine.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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