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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzonitrile
EC Number:
212-836-5
EC Name:
2-chlorobenzonitrile
Cas Number:
873-32-5
Molecular formula:
C7H4ClN
IUPAC Name:
2-chlorobenzonitrile
impurity 1
Reference substance name:
unknown
IUPAC Name:
unknown
Test material form:
solid

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Doses:
125, 200, 320, 500 and 800 mg/kg bw
No. of animals per sex per dose:
10 f
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
396 mg/kg bw
Based on:
test mat.
95% CL:
>= 321 - <= 488
Clinical signs:
other: jerkingly breathing, vestibular disorder, lateral or abdominal position

Any other information on results incl. tables

Dose [mg/kg bw]

Concentration [%]

Dead animals per dose group

125

1

0 of 10 rats

200

4

1 of 10 rats

320

4

3 of 10 rats

500

4

6 of 10 rats

800

4

10 of 10 rats

 

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of o-Chlorobenzonitrile administered to female rats is 396 mg/kg bw.
Executive summary:

2-chlorobenzonitrile was administered by gavage in a single dose of 125, 200, 320, 500 and 800 mg/kg to 10 female rats per dose. Animals were observed for 14 consecutive days. Mortality occurred in the test groups receiving >= 200 mg/kg bw.

The LD50 was calculated to be 396 mg/kg bw.