Registration Dossier
Registration Dossier
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EC number: 480-290-7 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
- Principles of method if other than guideline:
- Test procedure:
96/54/EG, B.42 (LLNA);
OECD 429 (2002)
Results and discussion
- Details on results:
- Compared to vehicle treated animals there was an increase
regarding the cell counts in the highest dose group. This
change was of statistical significance and the "positive
level" of index 1.4 was just exceeded.
A statistically significant increase compared to vehicle
treated animals regarding ear swelling and ear weight was
detected in the highest dose group. These results point to
an acute inflammatory reaction due to irritating properties
of the test item. An increase in this parameter would point
to an acute irritating (inflammatory) response.
Such an irritating property is also combined with a strong
skin sensitizing potential of a test compound, which,
however, was not detected here.
The results show that the test item has a moderate
sensitizing potential in mice after dermal application.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
