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EC number: 247-045-4 | CAS number: 25498-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
No specific studies for tripropylene glycol methyl ether are available. Two inhalation studies with propylene glycol methyl ether in rats and mice are available for read-across to tripropylene glycol methyl ether. Both studies are reliable without restrictions as they were conducted under GLP and according to OECD guideline 453.
Key value for chemical safety assessment
Carcinogenicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 25 312.88 mg/m³
Justification for classification or non-classification
No carcinogenic effect as evidenced by any increase in tumor incidence occurred from exposure to propylene glycol methyl ether at any concentration in either species.
Additional information
Repeated exposure to tripropylene glycol methyl ether resulted in toxicity only at high exposure levels and usually consisted of increased organ weights without accompanying histopathology. In vitro genotoxicty studies are negative, indicating that tripropylene glycol methyl ether is not genotoxic. No carcinogenicity studies are available for tripropylene glycol methyl ether. The sole propylene glycol ether that has been subjected to chronic toxicity/carcinogenicity testing is propylene glycol methyl ether. The glycol ethers propylene glycol methyl ether (PGME), dipropylene glycol methyl ether (DPGME) and tripropylene glycol methyl ether (TPGME) are closely related in molecular structure and physicochemical properties and thus, the potential for toxicological effects. They are liquids with similar boiling points, moderate volatility, and high water solubility. Increasing boiling point and vapor pressure are consistent with increasing molecular weight. Metabolism of propylene glycol methyl ethers takes place predominantly in the liver where mixed function oxidase cleaves the ether linkage, yielding propylene glycol and an alcohol. These two byproducts may be consumed in intermediary metabolism to CO2 and water, with the latter ultimately being excreted in expired air. Alternatively, the parent ether (or intermediate metabolite) may be conjugated in the liver with glucuronide, sulfate, or glutathione for ultimate excretion, predominantly in the urine. As a class, the propylene glycol methyl ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure. Metabolism studies (by oral exposure) conducted with PGME and DPM support this conclusion. A higher proportion of PGME was eliminated via the lungs as opposed to the urine than the larger molecular weight DPGME. The ether bond may be broken via O-dealkylation by mixed function oxidase to yield mono-, di-, or tripropylene glycol (depending on the parent compound). The (mono-, di-, or tri-) propylene glycol released may then undergo further metabolism to yield CO2. Alternatively, propylene glycol methyl ethers or their partially metabolized by-products may be conjugated with glucuronide or sulfate and excreted via the kidneys into the urine. No differences in gene mutation potential have been observed between other glycol ethers families (e.g. mono- and di-propylene glycol n-propyl ethers and mono-, di- and tri-propylene glycol n-butyl ethers) and similar effects were observed in the repeated dose toxicity studies. The results of propylene glycol ethers were consistently negative in gene mutation studies. Thus, the propylene glycol methyl ether study is used as a surrogate for tripropylene glycol methyl ether. Propylene glycol methyl ether, tested by inhalation in rats and mice at concentrations up to 3,000 ppm, caused very little chronic toxicity and caused no cancer. Further justification for the use of read across is contained in the category document attached at section 13.
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