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Diss Factsheets
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EC number: 629-721-4 | CAS number: 308062-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16-10-1995 to 10-11-1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study is performed according to GLP and OECD 203 guideline but no specific chemical analysis was performed and the substance is insoluble in water. No stable emulsions could be prepared and after preparation of the test solutions the remaining undissolved substance was removed using a folding filter. Due to the strong sorbing properties of the test substance the use of the filter might have reduced the exposure concentration below the water solubility. The results are summarily described, no raw data are included in the report and no information on the purity of the test substance is given but as this is a fish study and acute fish studies are probably not critical for the hazard assessment the result will be used.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- testsubstance is added to a bekerglass en tapwater is added. Then, with the use of Ultra Turrax the suspension is homogenisized and added to a 10L glass container where it is diluted with tapwater and stirred for 72h with magentic stirring. The solution was filtered over a folding filter and the filtrate was clear and used for the tests.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- source: Hamilton-Buchanan
size 3.1-3.4 cm (mean = 3.4) which is outside the recommended range of 2 plus minus 1 cm. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 21.0-21.8 deg C
- pH:
- 7.6-8.3
- Dissolved oxygen:
- 5.8-9.7
- Nominal and measured concentrations:
- nominal: 100, 220, 500, 1000 mg/L
- Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 220 - 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- no data
- Reported statistics and error estimates:
- no data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The reliability of this study is low: The study is performed according to GLP and OECD 203 guideline but no specific chemical analysis was performed and the substance is insoluble in water. No stable emulsions could be prepared and after preparation of the test solutions the remaining undissolved substance was removed using a folding filter. Duo to the strong sorbing properties of the test substance the use of the filter might have reduced the exposure concentration below the water solubility.
The study report is not complete:
No raw data are included in the report and no information on the purity of the test substance is given. These points make the actual exposure uncertain en therefore the study is ranked 3. - Executive summary:
The toxicity of distearyl amine (Genamine SH 200) to zebrafish was determined according to OECD guideline 203 applying GLP conditions. The test substance is poorly soluble in water and no stable dispersions could be prepared. The remaining undissolved test substance was removed by filtration over a folding filter. Due to the sorptive properties a large fraction of the substance might be sorbed to the filter. It is therefore unclear to what concentration the test organisms were exposed.
Reference
Description of key information
Due to the limited solubility of test substance an effect range is reported of 220 - 500 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 220 mg/L
Additional information
The short-term toxicity fish tests available was conducted in a period when no reliable specific method of analyses was available. The concentrations were therefore not analytically verified, the reliability of the results is limited because of the poor solubility of the test substances and partial sorption onto the walls of test vessels. Hence, most of the tests were considered to be valid with restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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